N-formyl-D,L-phenylalanine methyl ester

Base Information

• Chemical Name: N-formyl-D,L-phenylalanine methyl ester
• CAS No.: 58298-90-1
• Molecular Formula: C₁₀H₁₁NO₃
• Molecular Weight: 193.202
• Mol file: 58298-90-1.mol

Synonyms:N-formyl-D,L-phenylalanine methyl ester

Chemical Property of N-formyl-D,L-phenylalanine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-formyl-D,L-phenylalanine methyl ester

There total 9 articles about N-formyl-D,L-phenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

carbon dioxide (124-38-9,18923-20-1) + phenylglycine methyl ester (24461-61-8,26682-99-5,37760-98-8,6591-61-3) → N-formyl-D,L-phenylalanine methyl ester (58298-90-1)

Guidance literature:

With CF₃O₃S^(1-)*C₂₅H₄₂N₆Rh⁽¹⁺⁾; diphenylsilane; In dichloromethane; at 25 ℃; for 24h; under 19001.3 Torr; High pressure; Autoclave;

DOI:10.1002/anie.201504072

Reference yield: 70.0%

formic acid (64-18-6) + methyl α-(p-methoxyphenylamino)-α-phenylacetate (125990-08-1) → N-formyl-D,L-phenylalanine methyl ester (58298-90-1)

Guidance literature:

formic acid; methyl α-(p-methoxyphenylamino)-α-phenylacetate; With acetic anhydride; for 2h; Heating;

With ammonium cerium(IV) nitrate; In water; acetonitrile; at 5 ℃; for 1h; Further stages.;

DOI:10.1016/j.tet.2007.11.106

Reference yield: 47.0%

sodium formate (141-53-7) + DL-2-phenylglycine methyl ester hydrochloride (15028-40-7,13226-98-7) → N-formyl-D,L-phenylalanine methyl ester (58298-90-1)

Guidance literature:

With formic acid; acetic anhydride; at 50 - 60 ℃; for 4h;

upstream raw materials:

formic acid

methyl α-(p-methoxyphenylamino)-α-phenylacetate

DL-2-phenylglycine methyl ester hydrochloride

trimethyl orthoformate

Downstream raw materials:

methyl 2-isocyano-2-phenylacetate

5-methoxy-4-phenyl-oxazole