ethyl 5-(4-chlorophenyl)-4-methyl-3-(4-sulfamoyl-5,6,7,8-tetrahydronaphthalen-1-yl)thiophene-2-carboxylate

Base Information

Chemical Name:ethyl 5-(4-chlorophenyl)-4-methyl-3-(4-sulfamoyl-5,6,7,8-tetrahydronaphthalen-1-yl)thiophene-2-carboxylate
CAS No.:1394373-00-2
Molecular Formula:C₂₄H₂₄ClNO₄S₂
Molecular Weight:490.044
Hs Code.:

Synonyms:ethyl 5-(4-chlorophenyl)-4-methyl-3-(4-sulfamoyl-5,6,7,8-tetrahydronaphthalen-1-yl)thiophene-2-carboxylate

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Chemical Property of ethyl 5-(4-chlorophenyl)-4-methyl-3-(4-sulfamoyl-5,6,7,8-tetrahydronaphthalen-1-yl)thiophene-2-carboxylate

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Technology Process of ethyl 5-(4-chlorophenyl)-4-methyl-3-(4-sulfamoyl-5,6,7,8-tetrahydronaphthalen-1-yl)thiophene-2-carboxylate

There total 6 articles about ethyl 5-(4-chlorophenyl)-4-methyl-3-(4-sulfamoyl-5,6,7,8-tetrahydronaphthalen-1-yl)thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1394375-51-9
methyl 5-bromo-4-methyl-3-(4-sulfamoyl-5,6,7,8-tetrahydronaphthalen-1-yl)thiophene-2-carboxylate

: 1679-18-1
4-Chlorophenylboronic acid

: 141-78-6
ethyl acetate

: 1394373-00-2
ethyl 5-(4-chlorophenyl)-4-methyl-3-(4-sulfamoyl-5,6,7,8-tetrahydronaphthalen-1-yl)thiophene-2-carboxylate

Guidance literature:: methyl 5-bromo-4-methyl-3-(4-sulfamoyl-5,6,7,8-tetrahydronaphthalen-1-yl)thiophene-2-carboxylate; 4-Chlorophenylboronic acid; With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; toluene; at 25 - 100 ℃; Inert atmosphere;

ethyl acetate; In hexane; at 25 ℃;

Reference yield: 35.0%

: 64-17-5
ethanol

: 1394375-51-9
methyl 5-bromo-4-methyl-3-(4-sulfamoyl-5,6,7,8-tetrahydronaphthalen-1-yl)thiophene-2-carboxylate

: 1679-18-1
4-Chlorophenylboronic acid

: 1394373-00-2
ethyl 5-(4-chlorophenyl)-4-methyl-3-(4-sulfamoyl-5,6,7,8-tetrahydronaphthalen-1-yl)thiophene-2-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In toluene; at 25 - 100 ℃; for 3h; Inert atmosphere;

Reference yield:

: 6134-55-0
5-bromotetralin

: 1394373-00-2
ethyl 5-(4-chlorophenyl)-4-methyl-3-(4-sulfamoyl-5,6,7,8-tetrahydronaphthalen-1-yl)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: chlorosulfonic acid / chloroform / 0 - 25 °C

2.1: tetrahydrofuran / 0 - 25 °C

3.1: potassium phosphate; triphenylphosphine / palladium diacetate / water; tetrahydrofuran / 25 - 75 °C / Inert atmosphere

4.1: bromine / dichloromethane / 0 - 25 °C

5.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 25 - 100 °C / Inert atmosphere

5.2: 25 °C

With chlorosulfonic acid; potassium phosphate; bromine; potassium carbonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; toluene;