2-[(DIETHYLAMINO)METHYL]CYCLOHEXANONE HYDROCHLORIDE

Base Information

• Chemical Name: 2-[(DIETHYLAMINO)METHYL]CYCLOHEXANONE HYDROCHLORIDE
• CAS No.: 37408-85-8
• Molecular Formula: C11H21 N O
• Molecular Weight: 183.294
• Hs Code.: 2922399090
• Mol file: 37408-85-8.mol

Synonyms:2-(N,N-Diethylaminomethyl)cyclohexanone;2-[(Diethylamino)methyl]cyclohexanone

Chemical Property of 2-[(DIETHYLAMINO)METHYL]CYCLOHEXANONE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.0122mmHg at 25°C
• Boiling Point: 260.4°C at 760 mmHg
• Flash Point: 82°C
• PSA: 20.31000
• LogP: 2.88950

Purity/Quality:

98% ^*data from raw suppliers

2-[(DIETHYLAMINO)METHYL]CYCLOHEXANONE HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[(DIETHYLAMINO)METHYL]CYCLOHEXANONE HYDROCHLORIDE

There total 10 articles about 2-[(DIETHYLAMINO)METHYL]CYCLOHEXANONE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-(Trimethylsilyloxy)cyclohexene (6651-36-1) + N-<(trimethylsiloxy)methyl>diethylamine (80202-61-5) → Hexamethyldisiloxane (107-46-0) + 2-[(diethylamino)methyl]-cyclohexanone (37408-85-8)

Guidance literature:

With trimethylsilyl iodide; In acetonitrile; at 20 ℃; for 1h;

Reference yield: 85.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + diethylamine (109-89-7) → 2-[(diethylamino)methyl]-cyclohexanone (37408-85-8)

Guidance literature:

With C₇H₁₃N₂O₃S⁽¹⁺⁾*C₁₀H₁₅O₄S^(1-); at 25 ℃; for 0.75h;

DOI:10.1016/j.molliq.2020.114370

Reference yield: 26.0%

dichloromethane (75-09-2) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + diethylamine (109-89-7) → 2-[(diethylamino)methyl]-cyclohexanone (37408-85-8)

Guidance literature:

In methanol; at 22 ℃; for 48h; under 6750540 Torr;

upstream raw materials:

formaldehyd

diethyl amine hydrochloride

cyclohexanone

diethyl(methoxymethyl)amine

Downstream raw materials:

2-diethylaminomethyl-cyclohexanol

Refernces

• 1、 Rochin, C.,Babot, O.,Dunogues, J.,Duboudin, F.. "A Convenient Regioselective Synthesis of Mannich Bases". . p. 667 - 668. Retrieved 2007/10/02.
• 2、 Hosomi, Akira,Iijima, Susumu,Sakurai, Hideki. "A NOVEL AMINOMETHYLATION OF SILYL ENOL ETHERS WITH AMINOMETHYL ETHERS CATALYZED BY IODOTRIMETHYLSILANE OR TRIMETHYLSILYL TRIFLUOROMETHANESULFONATE". . p. 547 - 550. Retrieved 2007/10/02.