3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-iodouridine

Base Information

• Chemical Name: 3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-iodouridine
• CAS No.: 364613-26-3
• Molecular Formula: C₃₆H₄₃IN₂O₇Si
• Molecular Weight: 770.737
• Mol file: 364613-26-3.mol

Synonyms:3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-iodouridine

Chemical Property of 3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-iodouridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-iodouridine

There total 1 articles about 3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-iodouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyldimethylsilyl chloride (18162-48-6) + 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-iodouridine (104375-88-4) → 3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-iodouridine (364613-26-3)

Guidance literature:

With 1-methyl-1H-imidazole; iodine; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

Reference yield: 88.0%

Dimethyldisulphide (624-92-0) + 3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-iodouridine (364613-26-3) → 3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityI)-2'-deoxy-5-methylthiouridine (1256466-55-3)

Guidance literature:

3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-iodouridine; With hydrogen; sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h;

Dimethyldisulphide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1.75h;

Reference yield: 68.0%

diphenyl ditelluride (32294-60-3) + 3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-iodouridine (364613-26-3) → 3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-phenyltellurouridine (1256466-65-5) + 1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-tetrahydrofuran-2-yl]pyrimidine-2,4-dione (113051-53-9)

Guidance literature:

3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-iodouridine; With hydrogen; sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h;

diphenyl ditelluride; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

upstream raw materials:

tert-butyldimethylsilyl chloride

2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-iodouridine

Downstream raw materials:

3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityI)-2'-deoxy-5-methylthiouridine

3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-phenyltellurouridine

1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-tetrahydrofuran-2-yl]pyrimidine-2,4-dione

1-[2'-deoxy-3'-O-(2-cyanoethyl-N,N-diisopropylamino)-phosphoramidite-5'-O-(4,4-dimethoxytrityl)-β-D-erythro-ribofuranosyl]-5-phenyltellurouridine