tert-butyl (2S)-3-hydroxy-1-[(2E)-2-(4-methoxybenzylidene)-1-methylhydrazinyl]-1-oxopropan-2-ylcarbamate

Base Information

• Chemical Name: tert-butyl (2S)-3-hydroxy-1-[(2E)-2-(4-methoxybenzylidene)-1-methylhydrazinyl]-1-oxopropan-2-ylcarbamate
• CAS No.: 1470363-23-5
• Molecular Formula: C₁₇H₂₅N₃O₅
• Molecular Weight: 351.403
• Mol file: 1470363-23-5.mol

Synonyms:tert-butyl (2S)-3-hydroxy-1-[(2E)-2-(4-methoxybenzylidene)-1-methylhydrazinyl]-1-oxopropan-2-ylcarbamate

Chemical Property of tert-butyl (2S)-3-hydroxy-1-[(2E)-2-(4-methoxybenzylidene)-1-methylhydrazinyl]-1-oxopropan-2-ylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (2S)-3-hydroxy-1-[(2E)-2-(4-methoxybenzylidene)-1-methylhydrazinyl]-1-oxopropan-2-ylcarbamate

There total 3 articles about tert-butyl (2S)-3-hydroxy-1-[(2E)-2-(4-methoxybenzylidene)-1-methylhydrazinyl]-1-oxopropan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C16H23N3O5 (1338211-01-0) + methyl iodide (74-88-4) → tert-butyl (2S)-3-hydroxy-1-[(2E)-2-(4-methoxybenzylidene)-1-methylhydrazinyl]-1-oxopropan-2-ylcarbamate (1470363-23-5)

Guidance literature:

With potassium carbonate; In acetone; at 50 ℃;

DOI:10.2174/15701786113109990028

Reference yield:

N-tert-butyloxycarbonyl-L-serine methyl ester (2766-43-0) → tert-butyl (2S)-3-hydroxy-1-[(2E)-2-(4-methoxybenzylidene)-1-methylhydrazinyl]-1-oxopropan-2-ylcarbamate (1470363-23-5)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 24 h

2: ethanol / 80 °C

3: potassium carbonate / acetone / 50 °C

With potassium carbonate; hydrazine hydrate; In ethanol; acetone;

DOI:10.2174/15701786113109990028

Reference yield:

tert-butyl (S)-(1-hydrazineyl-3-hydroxy-1-oxopropan-2-yl)carbamate (2766-42-9) + 4-methoxy-benzaldehyde (123-11-5) → tert-butyl (2S)-3-hydroxy-1-[(2E)-2-(4-methoxybenzylidene)-1-methylhydrazinyl]-1-oxopropan-2-ylcarbamate (1470363-23-5)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 80 °C

2: potassium carbonate / acetone / 50 °C

With potassium carbonate; In ethanol; acetone;

DOI:10.2174/15701786113109990028

upstream raw materials:

C₁₆H₂₃N₃O₅

methyl iodide

tert-butyl (S)-(1-hydrazineyl-3-hydroxy-1-oxopropan-2-yl)carbamate

4-methoxy-benzaldehyde