3-Hydroxypropanamide

Base Information

• Chemical Name: 3-Hydroxypropanamide
• CAS No.: 2651-43-6
• Molecular Formula: C3H7 N O2
• Molecular Weight: 89.0941
• Hs Code.: 29241990
• European Community (EC) Number: 640-063-7
• DSSTox Substance ID: DTXSID30399878
• Nikkaji Number: J26.753H
• Wikidata: Q82202642
• ChEMBL ID: CHEMBL170341
• Mol file: 2651-43-6.mol

Synonyms:3-hydroxypropanamide;2651-43-6;3-HYDROXYPROPIONAMIDE;Propanamide, 3-hydroxy-;3-Hydroxy-propionamide;CHEMBL170341;Methylolacetamid;3-hydroxy-propanamide;beta-hydroxypropionamide;beta-hydroxypropionic acid amide;DTXSID30399878;3-hydroxypropionamide, AldrichCPR;SMGLHFBQMBVRCP-UHFFFAOYSA-N;BDBM50224823;MFCD04039564;AKOS009592606;SB83806;AS-58062;CS-0205185;FT-0670051;EN300-79996;J-016458;Z431951940

Chemical Property of 3-Hydroxypropanamide

Chemical Property:

• Vapor Pressure: 1.52E-06mmHg at 25°C
• Melting Point: 60-62°C
• Refractive Index: 1.463
• Boiling Point: 357.4°C at 760 mmHg
• Flash Point: 169.9°C
• PSA: 63.32000
• Density: 1.166g/cm³
• LogP: -0.44560
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility.: DMSO (Soluble), Methanol (Slightly)
• XLogP3: -1.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 89.047678466
• Heavy Atom Count: 6
• Complexity: 52.8

Purity/Quality:

98%Min ^*data from raw suppliers

3-Hydroxypropionamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CO)C(=O)N
• Uses: 3-Hydroxypropionamide (cas# 2651-43-6) is a compound useful in organic synthesis.

Technology Process of 3-Hydroxypropanamide

There total 3 articles about 3-Hydroxypropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Hydroxypropionitrile (109-78-4) → 3-hydroxypropionamide (2651-43-6) + 3-hydroxypropionic acid (503-66-2)

Guidance literature:

With sulfuric acid; at 101.2 ℃; Rate constant; oth. temperature, E(activ.);

Reference yield:

β-Propiolactone (57-57-8) → 3-hydroxypropionamide (2651-43-6) + 3-amino propanoic acid (107-95-9)

Guidance literature:

With ammonium hydroxide; at 20 ℃; Reagent/catalyst; regioselective reaction; Sealed tube;

Reference yield:

β-Propiolactone (57-57-8) + ammonia (7664-41-7) → 3-hydroxypropionamide (2651-43-6) + 3-amino propanoic acid (107-95-9)

Guidance literature:

analoge Reaktionen mit primaeren und sekundaeren Aminen;

DOI:10.1021/ja01151a050

upstream raw materials:

3-Hydroxypropionitrile

β-Propiolactone

ammonia

Downstream raw materials:

ethyl acrylate

acrylonitrile

2-propenamide

dimethylenecyclourethane

Refernces

• 1、 Cavarzan, Alessandra,Scarso, Alessandro,Strukul, Giorgio. "Efficient nitrile hydration mediated by RuII catalysts in micellar media". experimental part. p. 790 - 794. Retrieved 2010/09/05.