benzyloxy-5-chloro-2-methoxy-3-toluene

Base Information

• Chemical Name: benzyloxy-5-chloro-2-methoxy-3-toluene
• CAS No.: 78135-48-5
• Molecular Formula: C₁₅H₁₅ClO₂
• Molecular Weight: 262.736
• Mol file: 78135-48-5.mol

Synonyms:benzyloxy-5-chloro-2-methoxy-3-toluene

Chemical Property of benzyloxy-5-chloro-2-methoxy-3-toluene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyloxy-5-chloro-2-methoxy-3-toluene

There total 6 articles about benzyloxy-5-chloro-2-methoxy-3-toluene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

benzyl bromide (100-39-0) + 2-chloro-5-hydroxy-3-methoxytoluene (78135-47-4) → benzyloxy-5-chloro-2-methoxy-3-toluene (78135-48-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 10h; Heating;

DOI:10.1002/hlca.19850680417

Reference yield:

methyl orsellinate (3187-58-4) → benzyloxy-5-chloro-2-methoxy-3-toluene (78135-48-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 95 percent / SOCl₂ / CH₂Cl₂ / 3 h / Heating

2: 72.5 percent / K₂CO₃ / acetone / 20 h / Heating

3: 74 percent / NaOH / H₂O / 4 h / Heating

4: 2,2'-bipyridyl, Cu₂O / bis-(2-methoxy-ethyl) ether / 2 h / Heating

5: 93 percent / K₂CO₃ / dimethylformamide / 10 h / Heating

With copper(I) oxide; [2,2]bipyridinyl; sodium hydroxide; thionyl chloride; potassium carbonate; In dichloromethane; diethylene glycol dimethyl ether; water; N,N-dimethyl-formamide; acetone;

DOI:10.1002/hlca.19850680417

Reference yield:

chloro-3-hydroxy-6-methoxy-4-methyl-2-benzoate de methyle (715-39-9) → benzyloxy-5-chloro-2-methoxy-3-toluene (78135-48-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / NaOH / H₂O / 4 h / Heating

2: 2,2'-bipyridyl, Cu₂O / bis-(2-methoxy-ethyl) ether / 2 h / Heating

3: 93 percent / K₂CO₃ / dimethylformamide / 10 h / Heating

With copper(I) oxide; [2,2]bipyridinyl; sodium hydroxide; potassium carbonate; In diethylene glycol dimethyl ether; water; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19850680417

upstream raw materials:

benzyl bromide

2-chloro-5-hydroxy-3-methoxytoluene

methyl orsellinate

chloro-3-dihydroxy-4,6-methyl-2-benzoate de methyle

Downstream raw materials:

2,2',4-tribenzyloxy-3,5,5'-trichloro-4'-methoxy-6,6'-dimethylbenzophenone

3,5,5'-trichloro-2,2'-dihydroxy-4,4'-dimethoxy-6,6'-dimethylbenzophenone

dichloro-3,3'-trihydroxy-4,6,6'-methoxy-4'-dimethyl-2,2'-benzophenone

tris(benzyloxy)-4,6,6'-dichloro-3,3'-methoxy-4'-dimethyl-2,2'-benzophenone