2-Difluoromethyl-benzoxazole

Base Information

Chemical Name:2-Difluoromethyl-benzoxazole
CAS No.:91437-09-1
Molecular Formula:C₈H₅F₂NO
Molecular Weight:169.131
Hs Code.:
DSSTox Substance ID:DTXSID90443947
Nikkaji Number:J999.660E
Wikidata:Q82261944
Mol file:91437-09-1.mol

Synonyms:2-DIFLUOROMETHYL-BENZOXAZOLE;91437-09-1;2-(DIFLUOROMETHYL)-1,3-BENZOXAZOLE;2-(Difluoromethyl)benzoxazole;DTXSID90443947;UDIPXWGWAFYJOU-UHFFFAOYSA-N;AKOS037648137;AT-0231

Suppliers and Price of 2-Difluoromethyl-benzoxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 2-Difluoromethyl-benzoxazole

Chemical Property:

PSA：26.03000
LogP:2.76540
XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:169.03392011
Heavy Atom Count:12
Complexity:165

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C2C(=C1)N=C(O2)C(F)F

Technology Process of 2-Difluoromethyl-benzoxazole

There total 6 articles about 2-Difluoromethyl-benzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 381-73-7
Difluoroacetic acid

: 95-55-6
2-amino-phenol

: 91437-09-1
2-(Difluoromethyl)benzoxazole

Guidance literature:: With triethylamine; triphenylphosphine; In tetrachloromethane; Heating;
DOI:10.1016/j.tetlet.2007.03.015

Reference yield: 71.0%

: 186828-50-2
2-(1-bromodifluoromethyl)benzo-1,3-oxazole

: 91437-09-1
2-(Difluoromethyl)benzoxazole

Guidance literature:: With Tetrakis(dimethylamino)ethylen; In N,N-dimethyl-formamide; at -20 - 20 ℃; for 3h;
DOI:10.1016/S0040-4039(01)00873-5

Reference yield: 62.0%

: 100-52-7
benzaldehyde

: 186828-50-2
2-(1-bromodifluoromethyl)benzo-1,3-oxazole

: 186828-51-3
2-benzoxazol-2-yl-2,2-difluoro-1-phenyl-1-ethanol

: 91437-09-1
2-(Difluoromethyl)benzoxazole

Guidance literature:: With Tetrakis(dimethylamino)ethylen; In N,N-dimethyl-formamide; 1.) -20 deg C, 1 h, 2.) -20 deg C to room temperature, 2 h;
DOI:10.1021/jo980201+