4(R)-(3-methoxycarbonylphenyl)-3(R),4-dimethyl-1-tertbutyloxycarbonylpiperidine

Base Information

Chemical Name:4(R)-(3-methoxycarbonylphenyl)-3(R),4-dimethyl-1-tertbutyloxycarbonylpiperidine
CAS No.:762299-37-6
Molecular Formula:C₂₀H₂₉NO₄
Molecular Weight:347.455
Hs Code.:

Synonyms:4(R)-(3-methoxycarbonylphenyl)-3(R),4-dimethyl-1-tertbutyloxycarbonylpiperidine

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Chemical Property of 4(R)-(3-methoxycarbonylphenyl)-3(R),4-dimethyl-1-tertbutyloxycarbonylpiperidine

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Technology Process of 4(R)-(3-methoxycarbonylphenyl)-3(R),4-dimethyl-1-tertbutyloxycarbonylpiperidine

There total 2 articles about 4(R)-(3-methoxycarbonylphenyl)-3(R),4-dimethyl-1-tertbutyloxycarbonylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 762299-36-5
3(R),4-dimethyl-4(R)-(3-trifluoromethanesulfonyloxyphenyl)-1-tert-butyloxycarbonylpiperidine

: 762299-37-6
4(R)-(3-methoxycarbonylphenyl)-3(R),4-dimethyl-1-tertbutyloxycarbonylpiperidine

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine; In dimethyl sulfoxide; at 65 ℃;
DOI:10.1016/j.bmcl.2003.09.012

Reference yield:

: 119193-19-0
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

: 762299-37-6
4(R)-(3-methoxycarbonylphenyl)-3(R),4-dimethyl-1-tertbutyloxycarbonylpiperidine

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / Et₃N / tetrahydrofuran / 25 °C

2: 74 percent / Et₃N / CH₂Cl₂ / 25 °C

3: 75 percent / Pd(OAc)2; DPPF; Et₃N / dimethylsulfoxide / 65 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2003.09.012