2-chlorophenylbutyric acid

Base Information

• Chemical Name: 2-chlorophenylbutyric acid
• CAS No.: 188014-56-4
• Molecular Formula: C₁₀H₁₁ClO₂
• Molecular Weight: 198.649
• Mol file: 188014-56-4.mol

Synonyms:2-chlorophenylbutyric acid

Chemical Property of 2-chlorophenylbutyric acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chlorophenylbutyric acid

There total 3 articles about 2-chlorophenylbutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2'-chloro-benzeneacetic acid (2444-36-2) + ethyl iodide (75-03-6) → 2-chlorophenylbutyric acid (188014-56-4)

Guidance literature:

2'-chloro-benzeneacetic acid; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 0 ℃;

ethyl iodide; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1002/adsc.200800532

Reference yield:

2'-chloro-benzeneacetic acid (2444-36-2) + ethyl bromide (74-96-4) → 2-chlorophenylbutyric acid (188014-56-4)

Guidance literature:

2'-chloro-benzeneacetic acid; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 - 25 ℃;

ethyl bromide; In tetrahydrofuran; hexanes; at 20 - 25 ℃; for 16h;

DOI:10.1002/adsc.200900538

Reference yield:

1-Chloro-2-(2-propenyl)benzene (1587-07-1) + benzene-1,3,5-triyl triformate → 2-chlorophenylbutyric acid (188014-56-4) + 3-(2-chlorophenyl)-2-methylpropanoic acid (880653-63-4) + 4-(2-chlorophenyl)butanoic acid (68449-31-0)

Guidance literature:

With formic acid; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; at 100 ℃; Overall yield = 78 %; Overall yield = 59.3 mg; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.9b02047

upstream raw materials:

2'-chloro-benzeneacetic acid

ethyl iodide

ethyl bromide

1-Chloro-2-(2-propenyl)benzene

Downstream raw materials:

2-(2-chlorophenyl)butanoyl chloride

2-(2-chlorophenyl)but-1-en-1-one

2-(2-chlorophenyl)-N-(2-(pyrrolidin-1-yl)phenyl)butanamide

Refernces

• 1、 Dong, Xiao-Yang,Du, Xuan-Yi,Fang, Jia-Heng,Gu, Qiang-Shuai,Li, Zhong-Liang,Liu, Xin-Yuan,Wang, Li-Lei,Xia, Hai-Dong. "Photoinduced Copper-Catalyzed Asymmetric Decarboxylative Alkynylation with Terminal Alkynes". supporting information. p. 16926 - 16932. Retrieved 2020/08/25.
• 2、 Concellon, Carmen,Duguet, Nicolas,Smith, Andrew D.. "N-heterocyclic carbene-mediated enantioselective addition of phenols to unsymmetrical alkylarylketenes". supporting information; experimental part. p. 3001 - 3009. Retrieved 2010/03/26.