N4-(3-aMinophenyl)-5-fluoro-N2-(4-(2-Methoxyethoxy)phenyl)pyriMidine-2,4-diaMine

Base Information

• Chemical Name: N4-(3-aMinophenyl)-5-fluoro-N2-(4-(2-Methoxyethoxy)phenyl)pyriMidine-2,4-diaMine
• CAS No.: 1202759-91-8
• Molecular Formula: C₁₉H₂₀FN₅O₂
• Molecular Weight: 369.399
• Mol file: 1202759-91-8.mol

Synonyms:N⁴-(3-aminophenyl)-5-fluoro-N²-(4-(2-methoxyethoxy)phenyl)pyrimidine-2,4-diamine

Chemical Property of N4-(3-aMinophenyl)-5-fluoro-N2-(4-(2-Methoxyethoxy)phenyl)pyriMidine-2,4-diaMine

Chemical Property:

• Boiling Point: 582.5±60.0 °C(Predicted)
• PKA: 4.07±0.10(Predicted)
• Density: 1.329±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

N4-(3-Aminophenyl)-5-fluoro-N2-(4-(2-methoxyethoxy)phenyl)pyrimidine-2,4-diamineHydrochloricAcidSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N4-(3-aMinophenyl)-5-fluoro-N2-(4-(2-Methoxyethoxy)phenyl)pyriMidine-2,4-diaMine

There total 11 articles about N4-(3-aMinophenyl)-5-fluoro-N2-(4-(2-Methoxyethoxy)phenyl)pyriMidine-2,4-diaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

5-fluoro-N2-(4-(2-methoxyethoxy)phenyl)-N4-(4-nitrophenyl)pyrimidine-2,4-diamine → N4-(3-aminophenyl)-5-fluoro-N2-(4-(2-methoxyethoxy)phenyl)pyrimidine-2,4-diamine (1202759-91-8)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; at 80 ℃; for 2h; Inert atmosphere;

Reference yield:

5-fluoro-N2-(4-(2-methoxyethoxy)phenyl)-N4-(3-nitrophenyl)pyrimidine-2,4-diamine → N4-(3-aminophenyl)-5-fluoro-N2-(4-(2-methoxyethoxy)phenyl)pyrimidine-2,4-diamine (1202759-91-8)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; at 80 ℃; for 2h;

Reference yield:

tert-butyl (3-((2-chloro-5-fluoropyrimidin-4-yl)amino)phenyl)carbamate (1202759-89-4) + 4-(2-methoxyethoxy)aniline (33311-29-4) → N4-(3-aminophenyl)-5-fluoro-N2-(4-(2-methoxyethoxy)phenyl)pyrimidine-2,4-diamine (1202759-91-8) + tert-butyl (3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino) pyrimidin-4-yl)amino)phenyl)carbamate (1202759-90-7)

Guidance literature:

With acetic acid; In tert-Amyl alcohol; for 4h; Reflux;

upstream raw materials:

4-(2-methoxyethoxy)aniline

tert-butyl (3-((2-chloro-5-fluoropyrimidin-4-yl)amino)phenyl)carbamate

3-nitro-aniline

tert-butyl (3-nitrophenyl)carbamate

Downstream raw materials:

ethyl 3-((3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)amino)-3-oxopropanoate

N-(3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-3-hydroxypropanamide

3-((3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)amino)-2-hydroxy-3-oxopropyl methanesulfonate

N-(3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)oxirane-2-carboxamide

Refernces

• 1、 -. "BENZENESULFONAMIDE DERIVATIVES AND USES THEREOF". . . Retrieved 2021/02/12.
• 2、 -. "HETEROARYL COMPOUNDS AND USES THEREOF". . . Retrieved 2014/07/08.