2-Methyl-2-propenyl p-tolyl sulphone

Base Information

• Chemical Name: 2-Methyl-2-propenyl p-tolyl sulphone
• CAS No.: 16192-04-4
• Molecular Formula: C11H14 O2 S
• Molecular Weight: 210.297
• European Community (EC) Number: 668-001-4
• DSSTox Substance ID: DTXSID90167277
• Nikkaji Number: J452.777A
• Wikidata: Q83036616
• Mol file: 16192-04-4.mol

Synonyms:2-Methyl-2-propenyl p-tolyl sulphone;16192-04-4;1-methyl-4-(2-methylprop-2-enylsulfonyl)benzene;2-METHYLALLYL P-TOLYL SULFONE;DTXSID90167277;AKOS024324430;1-methyl-4-(2-methylallylsulfonyl)benzene;4-methylphenyl 2-methyl-2-propenyl sulfone;1-Methyl-4-((2-methylallyl)sulfonyl)benzene;AG-803/40869717

Chemical Property of 2-Methyl-2-propenyl p-tolyl sulphone

Chemical Property:

• Vapor Pressure: 0.000104mmHg at 25°C
• Boiling Point: 348.1°C at 760 mmHg
• Flash Point: 192.9°C
• Density: 1.095g/cm³
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 210.07145086
• Heavy Atom Count: 14
• Complexity: 290

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)CC(=C)C

Technology Process of 2-Methyl-2-propenyl p-tolyl sulphone

There total 17 articles about 2-Methyl-2-propenyl p-tolyl sulphone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

toluene-4-sulfonic acid hydrazide (1576-35-8) + 3-Chloro-2-methylpropene (563-47-3) → 1-methyl-4-(2-methylallylsulfonyl)benzene (16192-04-4)

Guidance literature:

With sodium acetate; In ethanol; for 16h; Heating;

DOI:10.1016/S0040-4020(01)89148-1

Reference yield: 86.0%

4-toluenesulfonyl azide (941-55-9) + β-methallyltriphenylstannane (2591-44-8) → 1-methyl-4-(2-methylallylsulfonyl)benzene (16192-04-4) + N-(2-methylallyl)-4-toluenesulfonamide (1206-41-3) + toluene-4-sulfonamide (70-55-3)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); In benzene; for 3h; Heating;

DOI:10.1039/p19960001493

Reference yield: 78.0%

sodium 4-methylbenzenesulfinate (824-79-3) + 3-Chloro-2-methylpropene (563-47-3) → 1-methyl-4-(2-methylallylsulfonyl)benzene (16192-04-4)

Guidance literature:

In N,N-dimethyl-formamide; at 60 ℃; for 3h;

DOI:10.1002/anie.201007571

upstream raw materials:

vinylmagnesium chloride

1-((2-(chloromethyl)allyl)sulfonyl)-4-methylbenzene

p-toluenesulfonyl chloride

toluene-4-sulfonic acid hydrazide

Downstream raw materials:

1-(2,4-Dimethyl-6-phenyl-hex-1-en-5-yne-3-sulfonyl)-4-methyl-benzene

5-Methyl-1,3-diphenyl-4-(toluene-4-sulfonyl)-hex-5-en-1-one

Dimethyl trans-4-bromomethyl-3-tosylmethylcyclopentane-1,1-dicarboxylate

Dimethyl cis-4-bromomethyl-3-tosylmethylcyclopentane-1,1-dicarboxylate

Refernces

• 1、 Jhang, Yin-Jia,Chang, Chieh-Yu,Lin, Yu-Huan,Lee, Chein-Chung,Wu, Yen-Ku. "Palladium-catalyzed substitution of allylic alcohols with sulfinate salts: A synthesis of bicalutamide". supporting information. . Retrieved 2021/05/04.
• 2、 Larraufie, Marie-Helene,Pellet, Remy,Fensterbank, Louis,Goddard, Jean-Philippe,Lacote, Emmanuel,Malacria, Max,Ollivier, Cyril. "Visible-light-induced photoreductive generation of radicals from epoxides and aziridines". supporting information; experimental part. p. 4463 - 4466. Retrieved 2011/06/22.