5-[1-hydroxy-1-(4-methoxymethoxyphenyl)methyl]-1-methyl-2-phenylthio-1H-imidazole

Base Information

Chemical Name:5-[1-hydroxy-1-(4-methoxymethoxyphenyl)methyl]-1-methyl-2-phenylthio-1H-imidazole
CAS No.:304442-80-6
Molecular Formula:C₁₉H₂₀N₂O₃S
Molecular Weight:356.445
Hs Code.:

Synonyms:5-[1-hydroxy-1-(4-methoxymethoxyphenyl)methyl]-1-methyl-2-phenylthio-1H-imidazole

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Chemical Property of 5-[1-hydroxy-1-(4-methoxymethoxyphenyl)methyl]-1-methyl-2-phenylthio-1H-imidazole

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Technology Process of 5-[1-hydroxy-1-(4-methoxymethoxyphenyl)methyl]-1-methyl-2-phenylthio-1H-imidazole

There total 1 articles about 5-[1-hydroxy-1-(4-methoxymethoxyphenyl)methyl]-1-methyl-2-phenylthio-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 6515-21-5
4-methoxymethoxy-benzaldehyde

: 79487-95-9
1-methyl-2-phenylsulfanyl-1H-imidazole

: 304442-80-6
5-[1-hydroxy-1-(4-methoxymethoxyphenyl)methyl]-1-methyl-2-phenylthio-1H-imidazole

Guidance literature:: 1-methyl-2-phenylsulfanyl-1H-imidazole; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; at 78 ℃; for 1.25h;

4-methoxymethoxy-benzaldehyde; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; at -78 ℃; for 2h;
DOI:10.3987/COM-00-8952

Reference yield: 100.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 304442-80-6
5-[1-hydroxy-1-(4-methoxymethoxyphenyl)methyl]-1-methyl-2-phenylthio-1H-imidazole

: 304442-81-7
5-[1-tert-butyldimethylsiloxy-1-(4-methoxymethoxyphenyl)methyl]-1-methyl-2-phenylthio-1H-imidazole

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 60 ℃;
DOI:10.3987/COM-00-8952

Reference yield:

: 304442-80-6
5-[1-hydroxy-1-(4-methoxymethoxyphenyl)methyl]-1-methyl-2-phenylthio-1H-imidazole

: 110189-03-2
4-((2-amino-4-(4-methoxybenzyl)-1-methyl-1H-imidazol-5-yl)methyl)phenol

Guidance literature:: Multi-step reaction with 11 steps

1.1: 100 percent / imidazole / dimethylformamide / 60 °C

2.1: 74.5 percent / N-bromosuccinimide / tetrahydrofuran / 3 h / 0 °C

3.1: tert-BuLi / pentane; diethyl ether / 0.5 h / -78 °C

3.2: 51.1 percent / pentane; diethyl ether / 3 h / -78 °C

4.1: 99 percent / Bu₄NF / tetrahydrofuran / 0.17 h / 20 °C

5.1: 31.2 percent / NiCl₂*6H₂O; NaBH₄ / methanol; tetrahydrofuran / 1.5 h / 20 °C

6.1: 71.4 percent / Zn powder; conc. HCl / acetic acid / 1 h / 80 °C

7.1: 87.5 percent / imidazole / dimethylformamide / 60 °C

8.1: 72.4 percent / N-bromosuccinimide / tetrahydrofuran / 1 h / 0 °C

9.1: tert-BuLi / pentane; diethyl ether / 0.5 h / -78 °C

9.2: 45.3 percent / trisylazide / pentane; diethyl ether / 1 h / -78 °C

10.1: 68.2 percent / H₂ / 10 percent Pd-C / ethanol / 3 h / 20 °C

11.1: 70 percent / Bu₄NF / tetrahydrofuran / 0.17 h / 20 °C

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; N-Bromosuccinimide; tetrabutyl ammonium fluoride; hydrogen; tert.-butyl lithium; nickel dichloride; zinc; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; acetic acid; N,N-dimethyl-formamide; pentane;
DOI:10.3987/COM-00-8952