4-Fluorophenylacetaldehyde diMethylacetal

Base Information

• Chemical Name: 4-Fluorophenylacetaldehyde diMethylacetal
• CAS No.: 121039-98-3
• Molecular Formula: C₁₀H₁₃FO₂
• Molecular Weight: 184.21
• Mol file: 121039-98-3.mol

Synonyms:2-(4-fluorophenyl)acetaldehyde dimethyl acetal

Chemical Property of 4-Fluorophenylacetaldehyde diMethylacetal

Chemical Property:

• Refractive Index: n20/D1.477
• Flash Point: 93℃
• Density: 1.074 g/mL at 25 °C

Purity/Quality:

99% ^*data from raw suppliers

1-(2,2-Dimethoxyethyl)-4-fluorobenzene ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36/37/38-52/53
• Safety Statements: 26-61

MSDS Files:

Useful:

Technology Process of 4-Fluorophenylacetaldehyde diMethylacetal

There total 2 articles about 4-Fluorophenylacetaldehyde diMethylacetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

methanol (67-56-1) + para-fluorostyrene (405-99-2) → 2-(4-fluorophenyl)acetaldehyde dimethyl acetal (121039-98-3)

Guidance literature:

With Pyridine-2,6-dicarboxylic acid; iron(II) tetrafluoroborate hexahydrate; [bis(acetoxy)iodo]benzene; at 20 ℃; for 20h; regioselective reaction; Molecular sieve; Inert atmosphere;

DOI:10.1039/c2cc17889c

Reference yield:

4-fluorophenylacetaldehyde (1736-67-0) + trimethyl orthoformate (149-73-5) → 2-(4-fluorophenyl)acetaldehyde dimethyl acetal (121039-98-3)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; at 20 ℃; for 24h;

DOI:10.2174/1573406412666160525121158

Reference yield:

2-(4-fluorophenyl)acetaldehyde dimethyl acetal (121039-98-3) → C10H12BrFO2

Guidance literature:

2-(4-fluorophenyl)acetaldehyde dimethyl acetal; With chloro-trimethyl-silane; sodium bromide; In methanol; at 40 ℃; for 0.0333333h;

With bromine; In methanol; acetonitrile; at 40 ℃; for 1h;

DOI:10.2174/1573406412666160525121158

upstream raw materials:

methanol

para-fluorostyrene

4-fluorophenylacetaldehyde

trimethyl orthoformate

Refernces

• 1、 Guryn, Roman,Staszewski, Marek,Kopczacki, Piotr,Walczyński, Krzysztof. "Non-imidazole histamine H3 ligands. Part VI. Synthesis and preliminary pharmacological investigation of thiazole-type histamine H3-receptor antagonists with lacking a nitrogen nucleus in the side chain". . p. 65 - 76. Retrieved 2017/06/05.
• 2、 Chowdhury, Abhishek Dutta,Lahiri, Goutam Kumar. "A generalized approach for iron catalyzed chemo- and regioselective formation of anti-Markovnikov acetals from styrene derivatives". supporting information; experimental part. p. 3448 - 3450. Retrieved 2012/05/20.