Benzyl 1,4-dioxa-7-azaspiro[4.4]nonane-7-carboxylate

Base Information

Chemical Name:Benzyl 1,4-dioxa-7-azaspiro[4.4]nonane-7-carboxylate
CAS No.:139524-57-5
Molecular Formula:C14H17NO4
Molecular Weight:263.293
Hs Code.:2934999090
DSSTox Substance ID:DTXSID30569418
Wikidata:Q82456567
Mol file:139524-57-5.mol

Synonyms:139524-57-5;Benzyl 1,4-dioxa-7-azaspiro[4.4]nonane-7-carboxylate;1,4-Dioxa-7-aza-spiro[4.4]nonane-7-carboxylic acid benzyl ester;CJAZZHHLJMGLNB-UHFFFAOYSA-N;SCHEMBL908529;DTXSID30569418;7-Benzyloxycarbonyl-1,4-dioxa-7-azaspiro[4,4]nonane;7-Benzyloxycarbonyl-1,4-dioxa-7-azaspiro[4.4]nonane

Suppliers and Price of Benzyl 1,4-dioxa-7-azaspiro[4.4]nonane-7-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1,4-DIOXA-7-AZA-SPIRO[4.4]NONANE-7-CARBOXYLIC ACID BENZYL ESTER 95.00%
5MG
$ 500.97

Total 5 raw suppliers

Chemical Property of Benzyl 1,4-dioxa-7-azaspiro[4.4]nonane-7-carboxylate

Chemical Property:

PSA：48.00000
LogP:1.70990
XLogP3:1.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:263.11575802
Heavy Atom Count:19
Complexity:321

Purity/Quality:

98% ^*data from raw suppliers

1,4-DIOXA-7-AZA-SPIRO[4.4]NONANE-7-CARBOXYLIC ACID BENZYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CC12OCCO2)C(=O)OCC3=CC=CC=C3

Technology Process of Benzyl 1,4-dioxa-7-azaspiro[4.4]nonane-7-carboxylate

There total 5 articles about Benzyl 1,4-dioxa-7-azaspiro[4.4]nonane-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 107-21-1
ethylene glycol

: 130312-02-6
benzyl 3-oxopyrrolidine-1-carboxylate

: 139524-57-5
N-(benzyloxycarbonyl)-7-aza-1,4-dioxospiro<4.4>nonane

Guidance literature:: With toluene-4-sulfonic acid; In benzene; for 20h; Heating / reflux;

Reference yield: 70.0%

: 130312-02-6
benzyl 3-oxopyrrolidine-1-carboxylate

: 107-15-3,85404-18-8
ethylenediamine

: 139524-57-5
N-(benzyloxycarbonyl)-7-aza-1,4-dioxospiro<4.4>nonane

Guidance literature:: With toluene-4-sulfonic acid; In toluene; at 130 ℃; for 96h;

Reference yield:

: 95656-88-5
benzyl 3-hydroxypyrrolidine-1-carboxylate

: 139524-57-5
N-(benzyloxycarbonyl)-7-aza-1,4-dioxospiro<4.4>nonane

Guidance literature:: Multi-step reaction with 2 steps

1: 5.6 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -60 - 20 °C

2: 6.8 percent / p-TsOH*H₂O / toluene / 16 h / Heating

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; toluene-4-sulfonic acid; In dichloromethane; toluene; 1: Swern oxidation;
DOI:10.1021/jm0604528