OXAZOLE, 4-(CHLOROMETHYL)-2-METHYL-

Base Information

• Chemical Name: OXAZOLE, 4-(CHLOROMETHYL)-2-METHYL-
• CAS No.: 141399-53-3
• Molecular Formula: C5H6 Cl N O
• Molecular Weight: 131.562
• Hs Code.: 2934999090
• Mol file: 141399-53-3.mol

Synonyms:OXAZOLE, 4-(CHLOROMETHYL)-2-METHYL-

Chemical Property of OXAZOLE, 4-(CHLOROMETHYL)-2-METHYL-

Chemical Property:

• Boiling Point: 183℃
• PKA: 0.87±0.12(Predicted)
• Flash Point: 64℃
• PSA: 26.03000
• Density: 1.202
• LogP: 1.72180
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-(Chloromethyl)-2-methyloxazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of OXAZOLE, 4-(CHLOROMETHYL)-2-METHYL-

There total 3 articles about OXAZOLE, 4-(CHLOROMETHYL)-2-METHYL- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxymethyl-2-methyloxazole (141567-53-5) → 4-(chloromethyl)-2-methyl-1,3-oxazole (141399-53-3) + 4-(bromomethyl)-2-methyl-1,3-oxazole (657389-99-6)

Guidance literature:

4-hydroxymethyl-2-methyloxazole; With methanesulfonyl chloride; triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 1h; Inert atmosphere;

With lithium bromide; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

Reference yield:

C5H8ClNO2 (1373958-90-7) → 4-(chloromethyl)-2-methyl-1,3-oxazole (141399-53-3)

Guidance literature:

C₅H₈ClNO₂; With thionyl chloride; In 1,2-dichloro-ethane; at 0 - 70 ℃;

With sodium hydrogencarbonate; In water; pH=8;

Reference yield:

acetamide (60-35-5) + 1,3-Dichloroacetone (534-07-6) → 4-(chloromethyl)-2-methyl-1,3-oxazole (141399-53-3)

Guidance literature:

With sodium hydrogencarbonate; In acetic acid; at 100 ℃;

upstream raw materials:

C₅H₈ClNO₂

acetamide

1,3-Dichloroacetone

4-hydroxymethyl-2-methyloxazole

Downstream raw materials:

5-chloro-3-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)-2-methyl-6-((2-methyloxazol-4-yl)methoxy)pyrimidin-4(3H)-one

N-methyl-1-(2-methyloxazol-4-yl)methanamine

5-[4-(2-Methyl-oxazol-4-ylmethoxy)-benzyl]-thiazolidine-2,4-dione