2-propylacetophenone

Base Information

• Chemical Name: 2-propylacetophenone
• CAS No.: 58632-83-0
• Molecular Formula: C11H14O
• Molecular Weight: 162.22826
• Mol file: 58632-83-0.mol

Synonyms:2-propylacetophenone;Ethanone, 1-(2-propylphenyl)- (9CI)

Chemical Property of 2-propylacetophenone

Chemical Property:

• PSA: 17.07000
• LogP: 2.84170

Purity/Quality:

99% ^*data from raw suppliers

2'-PROPYL ACETOPHENONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-propylacetophenone

There total 5 articles about 2-propylacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-(2-allylphenyl)ethan-1-one (64664-07-9) → 1-(2-propylphenyl)ethan-1-one (58632-83-0)

Guidance literature:

With 1,4-dioxane; bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,2-bis-(dicyclohexylphosphino)ethane; at 130 ℃; for 10h; chemoselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.9b01989

Reference yield: 48.0%

tetra-n-propylammonium bromide (1941-30-6) + acetophenone (98-86-2) → 1-(2-propylphenyl)ethan-1-one (58632-83-0)

Guidance literature:

With carbonyldihydridotris(triphenylphosphine)ruthenium(II); potassium hydroxide; In toluene; at 140 ℃; for 16h; Inert atmosphere; Glovebox;

DOI:10.1039/c9ob00243j

Reference yield:

(E)-4-methoxy-N-(1-phenylethylidene)benzenamine (2743-00-2,125231-22-3) + isopropyl bromide (75-26-3) → 1-(2-(propan-2-yl)phenyl)ethan-1-one (2142-65-6) + 1-(2-propylphenyl)ethan-1-one (58632-83-0)

Guidance literature:

(E)-4-methoxy-N-(1-phenylethylidene)benzenamine; isopropyl bromide; With neopentylmagnesium bromide; cobalt(II) bromide; 1,3-Diisopropyl-4,5-dihydro-3H-imidazol-1-ium tetrafluoroborate; In tetrahydrofuran; at 0 - 20 ℃; for 6h; Schlenk technique; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran; Overall yield = 68 %; Inert atmosphere; Schlenk technique;

DOI:10.1021/ja403759x

upstream raw materials:

2-propyl-benzoyl chloride

dimethylcadmium

(E)-4-methoxy-N-(1-phenylethylidene)benzenamine

isopropyl bromide

Downstream raw materials:

C₂₁H₂₄N₄O

1-ethyl-2-propyl-benzene