N-Trimethylsilylbenzamide

Base Information

• Chemical Name: N-Trimethylsilylbenzamide
• CAS No.: 1011-57-0
• Molecular Formula: C10H15NOSi
• Molecular Weight: 193.321
• Hs Code.: 2931900090
• Mol file: 1011-57-0.mol

Synonyms:Benzoyl-trimethylsilyl-amin;N-Trimethylsilyl-benzamid;N-trimethylsilanyl-benzamide;

Chemical Property of N-Trimethylsilylbenzamide

Chemical Property:

• PSA: 32.59000
• LogP: 2.82610

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Trimethylsilylbenzamide

There total 5 articles about N-Trimethylsilylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

chloro-trimethyl-silane (75-77-4) + benzamide (55-21-0,27208-38-4) → N-trimethylsilylbenzamide (1011-57-0)

Guidance literature:

With triethylamine; In diethyl ether; at 20 ℃; for 1h;

DOI:10.1039/c4cc02894e

Reference yield: 85.0%

benzoyl chloride (98-88-4) + 1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) → N-trimethylsilylbenzamide (1011-57-0)

Guidance literature:

In hexane; for 2h; Heating;

DOI:10.1021/jo00170a050

Reference yield: 61.0%

2-amino-4,5-benzo-1,3,2-dioxaphospholane (84635-79-0) + benzoic acid (65-85-0,8013-63-6) → N-trimethylsilylbenzamide (1011-57-0) + 2-trimethylsiloxy-4,5-benzo-1,3,2-dioxaphospholane (61706-76-1) + 2-<(trimethylsilyl)amino>-1,3,2-benzodioxaphosphole (133494-32-3)

Guidance literature:

at 120 ℃; for 1h;

DOI:10.1007/BF00959669

upstream raw materials:

chloro-trimethyl-silane

benzamide

benzoyl chloride

1,1,1,3,3,3-hexamethyl-disilazane

Downstream raw materials:

chloro-trimethyl-silane

1,1,3,3-tetramethyl-1,3-bis(benzamidomethyl)-1,3-disiloxane

2-amino-3,4,6-tri-O-benzyl-2-deoxy-1-O-2-N-(phenylmethan-yl-ylidene)-α-D-glucopyranose

N-((4-methoxyphenyl)(phenyl)methyl)benzamide

Refernces

• 1、 Bowser, James R.,Williams, Pamela J.,Kurz, Kenneth. "Cleavage of Silicon-Nitrogen Bonds by Acid Chlorides: An Unusual Synthetic Route to Amides". . p. 4111 - 4113. Retrieved 1983.
• 2、 Blondiaux, Enguerrand,Cantat, Thibault. "Efficient metal-free hydrosilylation of tertiary, secondary and primary amides to amines". supporting information. p. 9349 - 9352. Retrieved 2014/08/05.