1-Methyl-3-phenylpyrazol-5-carbonsaeure-methylester

Base Information

• Chemical Name: 1-Methyl-3-phenylpyrazol-5-carbonsaeure-methylester
• CAS No.: 10250-62-1
• Molecular Formula: C12H12N2O2
• Molecular Weight: 216.239
• Mol file: 10250-62-1.mol

Synonyms:methyl 1-methyl-3-phenyl-1H-pyrazole-5-carboxylate;<1-Methyl-3-phenyl-pyrazol-5-yl>-saeure-methylester;2-Methyl-5-phenyl-2H-pyrazol-3-carbonsaeure-methylester;methyl 1-methyl-3-phenylpyrazole-5-carboxylate;2-methyl-5-phenyl-2H-pyrazole-3-carboxylic acid methyl ester;

Chemical Property of 1-Methyl-3-phenylpyrazol-5-carbonsaeure-methylester

Chemical Property:

• PSA: 44.12000
• LogP: 1.87370

Purity/Quality:

97% ^*data from raw suppliers

Methyl1-Methyl-3-phenyl-1H-pyrazole-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Methyl-3-phenylpyrazol-5-carbonsaeure-methylester

There total 9 articles about 1-Methyl-3-phenylpyrazol-5-carbonsaeure-methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

methylhydrazine (60-34-4) + methyl 4-phenyl-2,4-dioxobutanoate (20577-73-5) → 1-Methyl-3-phenylpyrazol-5-carbonsaeure-methylester (10250-62-1) + methyl 1-methyl-5-phenyl-1H-pyrazole-3-carboxylate (10250-65-4)

Guidance literature:

In ethanol; for 5h; Heating / reflux;

Reference yield: 17.0%

N'-<α-bromobenzylidene>-N-methylhydrazinium bromide (90145-13-4) + propynoic acid methyl ester (922-67-8) → 1-Methyl-3-phenylpyrazol-5-carbonsaeure-methylester (10250-62-1) + 1-Methyl-3-phenylpyrazol-4-carbonsaeure-methylester (90145-22-5)

Guidance literature:

With triethylamine; In benzene; for 2h; Heating;

Reference yield:

1-benzylidene-2-methylhydrazine (13466-29-0) → 1-Methyl-3-phenylpyrazol-5-carbonsaeure-methylester (10250-62-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 63 percent / Br₂ / acetic acid / 2 h / Ambient temperature

2: 67 percent / Et₃N, hydroquinone / benzene / 4 h / Heating

3: chloranil / xylene / 6 h / Heating

With bromine; chloranil; triethylamine; hydroquinone; In acetic acid; xylene; benzene;

upstream raw materials:

diazomethane

methyl 5-phenyl-1H-pyrazole-3-carboxylate

diethyl ether

methyl iodide

Downstream raw materials:

2-Methyl-5-phenyl-2H-pyrazole-3-carboxylic acid