C₃₉H₃₂F₆N₄O

Base Information

• Chemical Name: C₃₉H₃₂F₆N₄O
• CAS No.: 1022155-26-5
• Molecular Formula: C₃₉H₃₂F₆N₄O
• Molecular Weight: 686.7
• Mol file: 1022155-26-5.mol

Synonyms:

Chemical Property of C₃₉H₃₂F₆N₄O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₉H₃₂F₆N₄O

There total 6 articles about C₃₉H₃₂F₆N₄O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-4-{[1-(trifluoromethyl)cyclopropyl]methyl}-1-trityl-1H-imidazole (1021736-30-0) + 1-(4-(1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethan-1-one (1022154-82-0) → C39H32F6N4O (1022155-26-5)

Guidance literature:

2-methyl-4-{[1-(trifluoromethyl)cyclopropyl]methyl}-1-trityl-1H-imidazole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h; Inert atmosphere;

1-(4-(1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethan-1-one; In tetrahydrofuran; hexane; at -78 ℃; for 2.66667h; Inert atmosphere;

DOI:10.1021/ml100196d

Reference yield:

1-trifluoromethyl-cyclopropanecarboxylic acid methoxy-methyl amide (1011460-56-2) → C39H32F6N4O (1022155-26-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ethylmagnesium bromide / diethyl ether; dichloromethane / 0.5 h / 5 °C

1.2: 19 h / 20 °C

2.1: hydrazine hydrate; potassium hydroxide / ethylene glycol / 2.33 h / 120 - 180 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere

3.2: 2.67 h / -78 °C / Inert atmosphere

With n-butyllithium; ethylmagnesium bromide; hydrazine hydrate; potassium hydroxide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; ethylene glycol;

DOI:10.1021/ml100196d

Reference yield:

(2-methyl-1-trityl-1H-imidazol-4-yl)-(1-trifluoromethyl-cyclopropyl)-methanone (1022154-58-0) → C39H32F6N4O (1022155-26-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrazine hydrate; potassium hydroxide / ethylene glycol / 2.33 h / 120 - 180 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere

2.2: 2.67 h / -78 °C / Inert atmosphere

With n-butyllithium; hydrazine hydrate; potassium hydroxide; In tetrahydrofuran; hexane; ethylene glycol;

DOI:10.1021/ml100196d

upstream raw materials:

1-trifluoromethyl-cyclopropanecarboxylic acid methoxy-methyl amide

(2-methyl-1-trityl-1H-imidazol-4-yl)-(1-trifluoromethyl-cyclopropyl)-methanone

2-methyl-4-{[1-(trifluoromethyl)cyclopropyl]methyl}-1-trityl-1H-imidazole

1-(4-(1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethan-1-one