N-Methoxy-N-MethylcinnaMaMide

Base Information

• Chemical Name: N-Methoxy-N-MethylcinnaMaMide
• CAS No.: 113474-86-5
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.23
• Hs Code.: 2924299090
• Mol file: 113474-86-5.mol

Synonyms:(E)-N-isopropyl-cinnamamide;(2E)-N-isopropyl-3-phenylacrylamide;trans-N-Isopropyl-zimtsaeureamid;(2E)-N-methoxy-N-methyl-3-phenylpropenamide;N-methoxy-N-methyl-3-phenyl-acrylamide;N-Isopropyl-trans-cinnamamid;(E)-N-methoxy-N-methyl-3-phenyl-2-propenamide;cinnamyl-N-isopropyl amide;(E)-N-methoxy-N-methyl-3-phenylprop-2-enamide;N-Isopropyl-3-phenyl-acrylamide;N-isopropyl-trans-cinnamamide;3-phenyl-(N-methoxy-N-methyl)propene amide;N-methoxy-N-methyl-(E)-3-phenyl-2-propenamide;

Chemical Property of N-Methoxy-N-MethylcinnaMaMide

Chemical Property:

• Melting Point: 56-59 °C
• Boiling Point: 274.9±33.0 °C(Predicted)
• PSA: 29.54000
• Density: 1.098±0.06 g/cm3(Predicted)
• LogP: 1.71960

Purity/Quality:

99% ^*data from raw suppliers

N-METHOXY-N-METHYLCINNAMAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Methoxy-N-MethylcinnaMaMide

There total 27 articles about N-Methoxy-N-MethylcinnaMaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-3-phenylacrylic acid (140-10-3) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → N-methoxy-N-methylcinnamamide (80783-99-9,124931-15-3,113474-86-5)

Guidance literature:

With 4-methyl-morpholine; In methanol; at 20 ℃;

DOI:10.1021/jo070646a

Reference yield: 100.0%

diethyl (N-methoxy-N-methylcarbamoylmethyl)phosphonate (124931-12-0) + benzaldehyde (100-52-7) → N-methoxy-N-methylcinnamamide (80783-99-9,124931-15-3,113474-86-5)

Guidance literature:

diethyl (N-methoxy-N-methylcarbamoylmethyl)phosphonate; With sodium hydride; In tetrahydrofuran; at 20 ℃;

benzaldehyde; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1055/s-0037-1610660

Reference yield: 96.0%

N-methoxy-N-methyl-2-(triphenylphosphoranylidene)acetamide (129986-67-0) + benzaldehyde (100-52-7) → N-methoxy-N-methylcinnamamide (80783-99-9,124931-15-3,113474-86-5)

Guidance literature:

In dichloromethane; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1248/CPB.C20-00545

upstream raw materials:

(E)-3-phenylacrylic acid

N,O-dimethylhydroxylamine*hydrochloride

diethyl (N-methoxy-N-methylcarbamoylmethyl)phosphonate

benzaldehyde

Downstream raw materials:

(E)-tert-butyl 3,5-dioxo-7-phenylhept-6-enoate

(E)-1-phenylnon-1-en-4-yn-3-one

(E)-3-phenylpropenal

(2E)-3-phenyl-2-propen-1-ol