Butanedioic acid, 2-(4-hydroxyphenyl)-, 1,4-diMethyl ester

Base Information

• Chemical Name: Butanedioic acid, 2-(4-hydroxyphenyl)-, 1,4-diMethyl ester
• CAS No.: 136705-25-4
• Molecular Formula: C12H14O5
• Molecular Weight: 238.24
• Hs Code.: 2918290000
• Mol file: 136705-25-4.mol

Synonyms:(4-hydroxy-phenyl)-succinic acid dimethyl ester;2-(4-hydroxyphenyl)-succinic acid dimethyl ester;(4-Hydroxy-phenyl)-bernsteinsaeure-dimethylester;Dimethyl 2-(4-hydroxyphenyl)succinate;

Chemical Property of Butanedioic acid, 2-(4-hydroxyphenyl)-, 1,4-diMethyl ester

Chemical Property:

• Boiling Point: 356.7±27.0 °C(Predicted)
• PKA: 9.56±0.26(Predicted)
• PSA: 72.83000
• Density: 1.225±0.06 g/cm3(Predicted)
• LogP: 1.21190
• Storage Temp.: 2-8°C

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Dimethyl2-(4-hydroxyphenyl)succinate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Butanedioic acid, 2-(4-hydroxyphenyl)-, 1,4-diMethyl ester

There total 10 articles about Butanedioic acid, 2-(4-hydroxyphenyl)-, 1,4-diMethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-(4-methoxy-phenyl)-succinic acid dimethyl ester (22248-26-6) + sodium hydrogencarbonate (144-55-8) → (4-hydroxy-phenyl)-succinic acid dimethyl ester (136705-25-4)

Guidance literature:

With thionyl chloride; aqueous HBr; In methanol;

Reference yield:

(E)-2-(4-Hydroxy-phenyl)-but-2-enedioic acid dimethyl ester → (4-hydroxy-phenyl)-succinic acid dimethyl ester (136705-25-4)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; under 2585.74 Torr;

DOI:10.1016/j.bmcl.2005.12.040

Reference yield:

p-Iodophenol (540-38-5) → (4-hydroxy-phenyl)-succinic acid dimethyl ester (136705-25-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Pd(OAc)2; (o-Tol)3P; TEA

2: H₂ / Pd(OH)2/C / methanol / 2585.74 Torr

With palladium diacetate; TEA; hydrogen; tris-(o-tolyl)phosphine; palladium dihydroxide; In methanol; 1: Heck coupling;

DOI:10.1016/j.bmcl.2005.12.040

upstream raw materials:

methanol

maleic anhydride

2-(4'-hydroxyphenyl)butane-1,4-dioic acid

para-iodoanisole

Downstream raw materials:

2-[3-formyl-4-(2-methoxy-ethoxymethoxy)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxa-borolan-2-yl)-phenyl]-succinic acid dimethyl ester

2-[5'-cyano-5-formyl-6,2'-bis-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-succinic acid dimethyl ester

2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-3'-cyano-6-hydroxy-biphenyl-3-yl]-succinic acid

2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-cyano-6,2'-dihydroxy-biphenyl-3-yl]-succinic acid