Formamide, N-phenyl-N-(phenylmethyl)-

Base Information

• Chemical Name: Formamide, N-phenyl-N-(phenylmethyl)-
• CAS No.: 16350-99-5
• Molecular Formula: C14H13NO
• Molecular Weight: 211.263
• Mol file: 16350-99-5.mol

Synonyms:Formanilide,N-benzyl;Ameisensaeure-phenylbenzylamid;Formamide,N-phenyl-N-(phenylmethyl);N-phenyl-N-(phenylmethyl)-formamide;N-benzylformanilide;N-Benzyl-formanilid;Formyl-benzylanilin;

Chemical Property of Formamide, N-phenyl-N-(phenylmethyl)-

Chemical Property:

• Melting Point: 45-46 °C
• Boiling Point: 148-162 °C
• PSA: 20.31000
• Density: 1.139±0.06 g/cm3(Predicted)
• LogP: 3.48550

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Formamide, N-phenyl-N-(phenylmethyl)-

There total 22 articles about Formamide, N-phenyl-N-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

formic acid (64-18-6) + N-Benzylaniline (758640-21-0,103-32-2) → N-benzylformanilide (16350-99-5)

Guidance literature:

formic acid; With acetic anhydride; at 70 ℃; for 1h; Inert atmosphere;

N-Benzylaniline; at 50 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.0c00432

Reference yield: 94.0%

benzyl bromide (100-39-0) + Formanilid (103-70-8) → N-benzylformanilide (16350-99-5)

Guidance literature:

Formanilid; With tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide; In toluene; at 20 ℃; for 2h; Inert atmosphere;

benzyl bromide; In toluene; at 80 - 90 ℃; for 3h; Inert atmosphere;

DOI:10.1021/om500603v

Reference yield: 89.0%

N-Benzylaniline (758640-21-0,103-32-2) + carbon dioxide (124-38-9,18923-20-1) → N-benzylformanilide (16350-99-5)

Guidance literature:

With diphenylsilane; C₂₁H₄₁N₃NiP₂; In acetonitrile; at 20 ℃; for 24h; under 6232.42 Torr; chemoselective reaction; Autoclave;

DOI:10.1039/c8cc05948a

upstream raw materials:

phenylammonium formate

benzaldehyde

benzyl chloride

ethyl N-phenylformimidate

Downstream raw materials:

N-benzyl-N-phenyl thioformamide

N-Benzylaniline

1-benzyl-3,4-dipropylquinolin-2(1H)-one

N-methyl-N-phenyl-benzenemethanamine