Ethyl 2-(Methylamino)-2-Oxoacetate

Base Information

• Chemical Name: Ethyl 2-(Methylamino)-2-Oxoacetate
• CAS No.: 18522-95-7
• Molecular Formula: C5H9NO3
• Molecular Weight: 131.131
• Mol file: 18522-95-7.mol

Synonyms:

Chemical Property of Ethyl 2-(Methylamino)-2-Oxoacetate

Chemical Property:

• Melting Point: 24 °C
• PKA: 12.77±0.46(Predicted)
• PSA: 55.40000
• Density: 1.088±0.06 g/cm3(Predicted)
• LogP: -0.31360
• Storage Temp.: Refrigerator
• Solubility.: Chloroform; Dichloromethane; Ethyl Acetate; Methanol; DMF

Purity/Quality:

97% ^*data from raw suppliers

ethyl2-(methylamino)-2-oxoacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 2-(Methylamino)-2-Oxoacetate

There total 6 articles about Ethyl 2-(Methylamino)-2-Oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Ethyl oxalyl chloride (4755-77-5) + methylamine (74-89-5) → ethyl N-methyloxamate (18522-95-7)

Guidance literature:

for 24h;

DOI:10.1021/acs.jmedchem.7b00443

Reference yield: 85.0%

N,N'-Dimethylurea (96-31-1) + oxalic acid diethyl ester (95-92-1) → 1,3-dimethylparabanic acid (5176-82-9) + Ethyl N-methylcarbamate (105-40-8) + ethyl N-methyloxamate (18522-95-7)

Guidance literature:

With di(n-butyl)tin oxide; at 140 ℃; for 12h; Inert atmosphere;

DOI:10.1002/aoc.1629

Reference yield: 72.88%

methylamine hydrochloride (593-51-1) + Ethyl oxalyl chloride (4755-77-5) → ethyl N-methyloxamate (18522-95-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; at -10 - 25 ℃; for 16h;

upstream raw materials:

oxalic acid diethyl ester

methylamine

N,N'-Dimethylurea

Ethyl oxalyl chloride

Downstream raw materials:

4-methyl-2-(N-methylcarbamoyl)-1 H-benzimidazole

benzoylhydrazono-methylamino-acetic acid ethyl ester

methylamino-(2-oxo-2-phenyl-ethylimino)-acetic acid ethyl ester

benzimidazole-2-carboxylic acid N-methylamide