105-40-8Relevant articles and documents
1,3-Dialkyl-3-acyltriazenes: Products and Rates of Decomposition in Acidic and Neutral Solutions
Smith, Richard H.,Wladkowski, Brian D.,Herling, Julie A.,Pfalzgraff, Timothy D.,Pruski, Brunon,et al.
, p. 654 - 661 (1992)
The products and mechanism of hydrolytic decomposition of a series of 1,,3-dialkyl-3-acyltriazenes were studied in both acidic and neutral buffers.In the acidic region, the products are alkyl alcohols derived from the N(1) alkyl group and amides derived from the intact N(3) portion of the molecule.The solvent deuterium isotope effect (kH2O/kD2O)) is less than 1.0.The mechanism is specific acid catalyzed, involving rapid reversible protonation of the 3-acyl group followed by scision of the N(2)-N(3) bond to generate an amide and an alkyl diazonium ion.The (2-hydroxyethyl)diazonium ion gives ethylene glycol and acetaldehyde, while the (2-chloroethyl)diazonium ion yields 2-chloroethanol.In the neutral region, the products are similar to those found in acidic buffers, alkyl alcohols, and amides.At this pH the (2-chloroethyl)diazonium ion produces ethylene glycol and acetaldehyde in addition to 2-chloroethanol.The solvent deuterium isotope effect (kH2O/kD2O) is greater than 1.0.The mechanism involves unimolecular heterolylsis of the N(2)-N(3) bond to form an amide anion and an alkyldiazonium ion.The methyldiazonium ion leads to incorporation of deuterium in the methyl group of the products, indicating the existence of an equilibrium between the metastable methyldiazonium ion and diazomethane.
CARBAMATE PREPARATION BY NITROMETHANE CARBONYLATION
Lapidus, A. L.,Pirozhkov, S. D.,Tumanova, A. R.
, p. 1049 (1988)
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A Class of N-O-Type Oxidants to Access High-Valent Palladium Species
Nappi, Manuel,Gaunt, Matthew J.
, p. 143 - 148 (2018/12/11)
This article presents a new class of mild reagents that is capable of oxidizing palladacycle(II) complexes to high-valent palladium species, promoting the formation of C-N bonds in stoichiometric and catalytic conditions. The weak N-O bond and the extremely electron-withdrawing benzenesulfonate group on the oxygen atom of the oxidant are crucial moieties to ensure the desired activity. The oxidation mechanism could involve outer-sphere single-electron transfer processes, opening the possibility for a complementary reactivity of Pd(IV) species.
COMPOSITIONS AND METHODS FOR THE TREATMENT OF RESTLESS LEG SYNDROME AND FIBROMYALGIA
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Paragraph 0122; 0123, (2015/05/26)
The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of fibromyalgia, restless leg syndrome may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of motor neurone disease, diabetic neuropathy, postherpetic neuralgia, acute opioid withdrawal management, obsessive-compulsive disorder, premature ejaculation, PTSD, injury, post-operative pain, osteoarthritis, rheumatoid arthritis, multiple sclerosis, spinal cord injury, migraine, HIV related neuropathic pain, bipolar depression, depression, stress, cancer pain and lower back pain.
Dibutyltin oxide catalyzed aminolysis of oxalate to carbamate, oxamate and derivatives of imidazolidine trione
Kunde, Lalita B.,Kalyani, Vishwanath S.,Gupte, Sunil P.
experimental part, p. 402 - 407 (2010/08/06)
Catalytic aminolysis of oxalates by simple and substituted ureas has been shown to give carbamates, oxamates and derivatives of imidazolidine trione. Various substituted ureas and oxalates were screened to verify the applicability of the protocol. The rol
