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| CAS No.: | 367-51-1 |
|---|---|
| Name: | Sodium thioglycolate |
| Molecular Structure: | |
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|
|
| Formula: | C2H4NaO2S |
| Molecular Weight: | 114.1 |
| Synonyms: | Sodium 2-mercaptoethanoate;Sodium 2-sulfanylacetate;Sodium mercaptoacetate;Thioglycolic acid sodium salt;Aceticacid, mercapto-, monosodium salt (8CI,9CI);Mercaptoacetic acidsodium salt; |
| EINECS: | 206-696-4 |
| Density: | 1.311g/cm3 |
| Melting Point: | >300 °C(lit.) |
| Boiling Point: | 225.5 °C at 760 mmHg |
| Flash Point: | 99.8 °C |
| Solubility: | soluble |
| Appearance: | White solid |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 22-36/37/38 |
| Safety: | 22-38-36/37/38 |
| Transport Information: | UN 2811 |
| PSA: | 78.93000 |
| LogP: | -1.33390 |
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Specification
The CAS registry number of Sodium thioglycolate is 367-51-1. Its EINECS registry number is 206-696-4. The IUPAC name is sodium 2-sulfanylacetate. In addition, the molecular formula is C2H4NaO2S and the molecular weight is 115.10. It is also called acetic acid, mercapto-, monosodium salt. What's more, it is a kind of white solid and should be stored in a cool and dry place.
Physical properties about this chemical are: (1)ACD/LogP: 0.09; (2)ACD/LogD (pH 5.5): -2; (3)ACD/LogD (pH 7.4): -3.47; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 2; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 2; (11)Polar Surface Area: 62.6 Å2; (12)Flash Point: 99.8 °C; (13)Enthalpy of Vaporization: 50.9 kJ/mol; (14)Boiling Point: 225.5 °C at 760 mmHg; (15)Vapour Pressure: 0.0314 mmHg at 25°C.
Preparation of Sodium thioglycolate: it can be prepared by thioethanolate. Cool the thioethanolate to 5 °C at first. Then add sodium hydroxide solution into the thioethanolate slowly with stirring. When the solution becomes pink and separates stable crystallization, you can stop adding the sodium hydroxide. At last, after a series of cooling, filtration, crystallization and drying you can get the desired product. The equation is as follows:
Uses of Sodium thioglycolate: it can be used as analytics reagents for the determination of iron, molybdenum, silver and tin. And it can be used in preparation of bacteria culture. In addition, it can react with phenylhydrazono-malononitrile to get [cyano-(phenyl-hydrazono)-acetimidoylsulfanyl]-acetic acid. This reaction will need solvents methanol and H2O. The reaction time is 2 hours. The pH value of the reaction solution is 7. The yield is about 80%.
![Sodium thioglycolate can react with phenylhydrazono-malononitrile to get [cyano-(phenyl-hydrazono)-acetimidoylsulfanyl]-acetic acid](/UserFilesUpload/Uses of Sodium thioglycolate.jpg)
When you are using this chemical, please be cautious about it as the following:
This chemical is harmful if swallowed and irritating to eyes, respiratory system and skin. Whenever you will contact it, please wear suitable protective clothing. If contact it with skin, wash it immediately with plenty of ... (to be specified by the manufacturer). In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
(1)SMILES: [Na+].[O-]C(=O)CS
(2)InChI: InChI=1/C2H4O2S.Na/c3-2(4)1-5;/h5H,1H2,(H,3,4);/q;+1/p-1
(3)InChIKey: GNBVPFITFYNRCN-REWHXWOFAT
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | intravenous | 500mg/kg (500mg/kg) | BEHAVIORAL: TREMOR GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING | Journal of Pharmacology and Experimental Therapeutics. Vol. 118, Pg. 296, 1956. |
| monkey | LDLo | intravenous | 300mg/kg (300mg/kg) | BEHAVIORAL: COMA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Journal of Pharmacology and Experimental Therapeutics. Vol. 118, Pg. 296, 1956. |
| mouse | LD50 | intraperitoneal | 200mg/kg (200mg/kg) | National Technical Information Service. Vol. AD277-689, | |
| mouse | LD50 | intravenous | 422mg/kg (422mg/kg) | Japanese Journal of Antibiotics. Vol. 38, Pg. 137, 1985. | |
| mouse | LD50 | oral | 504mg/kg (504mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacology and Experimental Therapeutics. Vol. 118, Pg. 296, 1956. |
| mouse | LD50 | subcutaneous | 293mg/kg (293mg/kg) | Japanese Journal of Antibiotics. Vol. 41, Pg. 105, 1988. | |
| mouse | LD50 | unreported | 8200ug/kg (8.2mg/kg) | Canadian Journal of Technology. Vol. 34, Pg. 21, 1956. | |
| rabbit | LDLo | intravenous | 100mg/kg (100mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Journal of Pharmacology and Experimental Therapeutics. Vol. 35, Pg. 343, 1929. |
| rat | LD50 | intraperitoneal | 126mg/kg (126mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of Pharmacology and Experimental Therapeutics. Vol. 118, Pg. 296, 1956. |