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α-benzyloxy-α-phenyl-as-triazine-5-acetonitrile
A
sodium cyanide
B
5-benzoyl-6-methyl-3-phenyl-as-triazine
C
benzoic acid
Conditions | Yield |
---|---|
With sodium hydroxide In water; dimethyl sulfoxide | A n/a B 54% C n/a |
Conditions | Yield |
---|---|
at 22 - 27℃; | |
at 22 - 27℃; |
diethyl ether
bromocyane
sodium diethylmalonate
A
diethyl 2-cyanomalonate
B
1,1,2,2-tetracarboethoxy-ethylene
C
tetraethyl ethane-1,1,2,2-tetracarboxylate
D
sodium cyanide
bromocyane
ethanol
sodium diethylmalonate
A
diethyl 2-cyanomalonate
B
1,1,2,2-tetracarboethoxy-ethylene
C
tetraethyl ethane-1,1,2,2-tetracarboxylate
D
sodium cyanide
Conditions | Yield |
---|---|
With sodium hydroxide | |
With sodium hydroxide; ethanol | |
With sodium hydroxide at 200 - 300℃; |
diethyl oximidate
sodium ethanolate
A
diethyl imidocarbonate
B
sodium cyanide
The sodium cyanide. With the CAS registry number 143-33-9, it is also named as Hydrocyanic acid, sodium salt. The product's categories are Sodium Cyanide; Inorganics; Peroxidase Inhibitors; Essential Chemicals; Reagent Grade; Routine Reagents; Molecular Biology; Molecular Biology Reagents; Superoxide Dismutase. The structure of solid NaCN is related to that of sodium chloride. It is white crystals with faint odor of bitter almond, which is soluble in water, ammonia, ethanol and methanol. When contact with acid and water, it liberates very toxic gas. Additionally, this chemical should be sealed in the container and stored in the cool, ventilate and dry place. Keep Sodium Cyanide separate from alkali, acids and food additives.
Physical properties about sodium cyanide are:
(1)H-Bond Donor: 0; (2)H-Bond Acceptor: 2; (3)Rotatable Bond Count: 0; (4)Exact Mass: 48.992844; (5)MonoIsotopic Mass: 48.992844; (6)Topological Polar Surface Area: 23.8; (7)Heavy Atom Count: 3; (8)Formal Charge: 0; (9)Complexity: 12.8; (10)Covalently-Bonded Unit Count: 2.
Preparation of Sodium Cyanide:
It can be obtained by treating hydrogen cyanide with sodium hydroxide:
HCN + NaOH → NaCN + H2O
Uses of Sodium Cyanide:
It is mainly used to extract gold and other precious metals in mining.
4 Au + 8 NaCN + O2 + 2 H2O → 4 Na[Au(CN)2] + 4 NaOH
It is also used to kill or stun rapidly such as in illegal cyanide fishing and in collecting jars used by entomologists. What's more, this chemica is used in plastics, pharmaceuticals, pesticides, dyes, metallurgy, electroplating, mineral processing and other industries. In addition, it can react with cycloheptanone to get 4-cyanocycloheptanone. This reaction needs reagents Na2S2O8, Na2SO4 and solvent water at temperature of 80 °C. The reaction time is 5 hours. The yield is 35%.
Safety Information of Sodium Cyanide:
It is not only very toxic by inhalation, in contact with skin and if swallowed, but also very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. After contact with skin, wash immediately with plenty of soap-suds. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) This material and its container must be disposed of as hazardous waste. And people should avoid release it to the environment. Refer to special instructions / safety data sheets.
You can still convert the following datas into molecular structure:
1. SMILES:[C-]#N.[Na+]
2. InChI:InChI=1/CN.Na/c1-2;/q-1;+1
3. InChIKey:MNWBNISUBARLIT-UHFFFAOYAG
The toxicity data of Sodium Cyanide is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
bird - wild | LD50 | oral | 4mg/kg (4mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of Wildlife Diseases. Vol. 22, Pg. 538, 1986. |
chicken | LD50 | oral | 21mg/kg (21mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Journal of Wildlife Diseases. Vol. 22, Pg. 538, 1986. |
child | LDLo | oral | 100mg/kg (100mg/kg) | GASTROINTESTINAL: OTHER CHANGES | Forensic Science International. Vol. 38, Pg. 173, 1988. |
dog | LD50 | subcutaneous | 5360ug/kg (5.36mg/kg) | JAMA, Journal of the American Medical Association. Vol. 149, Pg. 113, 1952. | |
dog | LDLo | intravenous | 1300ug/kg (1.3mg/kg) | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 6, Pg. 349, 1947. | |
domestic animals - goat/sheep | LD50 | oral | 4mg/kg (4mg/kg) | Toxicology and Applied Pharmacology. Vol. 45, Pg. 359, 1978. | |
duck | LD50 | oral | 2500ug/kg (2.5mg/kg) | National Technical Information Service. Vol. OTS0530251, | |
frog | LDLo | parenteral | 60mg/kg (60mg/kg) | PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 166, Pg. 437, 1932. |
guinea pig | LD50 | subcutaneous | 5800ug/kg (5.8mg/kg) | Medicina del Lavoro. Industrial Medicine. Vol. 46, Pg. 221, 1955. | |
human | LDLo | oral | 2800ug/kg (2.8mg/kg) | National Technical Information Service. Vol. OTS0528336, | |
human | LDLo | oral | 2857ug/kg (2.857mg/kg) | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 191, 1969. | |
mammal (species unspecified) | LD50 | oral | 8mg/kg (8mg/kg) | Bulletin of Environmental Contamination and Toxicology. Vol. 23, Pg. 211, 1979. | |
man | LDLo | oral | 6557ug/kg (6.557mg/kg) | BEHAVIORAL: FLUID INTAKE GASTROINTESTINAL: GASTRITIS | Acta Pharmacologica et Toxicologica. Vol. 1, Pg. 18, 1945. |
man | LDLo | unreported | 2206ug/kg (2.206mg/kg) | "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. | |
man | TDLo | oral | 714ug/kg (0.714mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: MUSCLE WEAKNESS | Acta Pharmacologica et Toxicologica. Vol. 20, Pg. 291, 1963. |
mouse | LD50 | intraperitoneal | 4900ug/kg (4.9mg/kg) | National Technical Information Service. Vol. OTS0528336, | |
mouse | LD50 | subcutaneous | 3600ug/kg (3.6mg/kg) | American Journal of Physiology. Vol. 179, Pg. 60, 1954. | |
mouse | LD50 | unreported | 10mg/kg (10mg/kg) | Igaku No Ayumi. Progress in Medicine. Vol. 112, Pg. 861, 1980. | |
quail | LD50 | oral | 8500ug/kg (8.5mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of Wildlife Diseases. Vol. 22, Pg. 538, 1986. |
rabbit | LD50 | intramuscular | 1666ug/kg (1.666mg/kg) | Journal of the American College of Toxicology. Vol. 1(3), Pg. 120, 1982. | |
rabbit | LD50 | ocular | 5048ug/kg (5.048mg/kg) | Journal of the American College of Toxicology. Vol. 1(3), Pg. 120, 1982. | |
rabbit | LD50 | skin | 10400ug/kg (10.4mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: TREMOR | National Technical Information Service. Vol. OTS0536153, |
rabbit | LDLo | subcutaneous | 2200ug/kg (2.2mg/kg) | JAMA, Journal of the American Medical Association. Vol. 100, Pg. 1920, 1933. | |
rat | LD50 | intraperitoneal | 4300ug/kg (4.3mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(12), Pg. 90, 1978. | |
rat | LD50 | oral | 6440ug/kg (6.44mg/kg) | "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972Vol. -, Pg. 13, 1972. | |
women | LDLo | oral | 40mg/kg (40mg/kg) | GASTROINTESTINAL: OTHER CHANGES | Forensic Science International. Vol. 38, Pg. 173, 1988. |