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Thiabendazole

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Name

Thiabendazole

EINECS 205-725-8
CAS No. 148-79-8 Density 1.406 g/cm3
PSA 69.81000 LogP 2.68640
Solubility 0.005 g/100 mL in water Melting Point 298-301 °C
Formula C10H7N3S Boiling Point 446 °C at 760 mmHg
Molecular Weight 201.252 Flash Point 226.2 °C
Transport Information UN 3077 9/PG 3 Appearance light yellow powder
Safety 60-61-36-26 Risk Codes 50/53-36/37/38
Molecular Structure Molecular Structure of 148-79-8 (Thiabendazole) Hazard Symbols IrritantXi,DangerousN
Synonyms

Thibenzole 200;Mertect 160;MK 360;Tiabenda;Benzimidazole, 2- (4-thiazolyl)-;E-Z-Ex;4-(2-benzimidazolyl)thiazole;Polival;Hokustar HP;2-(4-Thiazolyl)-1H-benzimidazole;2-(4-Thiazolyl)benzimidazole;Bovizole;TectiviridaeTectivirusTecto;Pitrizet;Syntol M 100;MK-360;

Article Data 50

Thiabendazole Synthetic route

C10H9N3S*ClH

148-79-8

thiabendazole

Conditions
ConditionsYield
With sodium hypochlorite; sodium carbonate In methanol; water at 0 - 65℃; for 1.5h; pH=9 - 10;97.82%
Stage #1: C10H9N3S*ClH With sodium carbonate In methanol; water at 0 - 5℃; for 0.333333h;
Stage #2: With sodium hypochlorite In methanol; water at 5 - 65℃; for 2h;
1452-15-9

thiazole-4-carbonitrile

95-54-5

1,2-diamino-benzene

50-81-7

ascorbic acid

148-79-8

thiabendazole

Conditions
ConditionsYield
With hydrogenchloride; ethylenediaminetetraacetic acid In water92.7%
1452-15-9

thiazole-4-carbonitrile

39145-59-0

o-phenylenediamine hydrochloride

95-54-5

1,2-diamino-benzene

50-81-7

ascorbic acid

148-79-8

thiabendazole

Conditions
ConditionsYield
With hydrogenchloride; ethylenediaminetetraacetic acid In methanol; water91.7%
With hydrogenchloride; ethylenediaminetetraacetic acid In water
3973-08-8

Thiazole-4-carboxylic acid

95-54-5

1,2-diamino-benzene

148-79-8

thiabendazole

Conditions
ConditionsYield
Stage #1: 1,2-diamino-benzene With polyphosphoric acid at 150℃; Inert atmosphere;
Stage #2: Thiazole-4-carboxylic acid at 230℃; for 2h; Reagent/catalyst; Temperature; Inert atmosphere;
88%
With polyphosphoric acid for 3h; Reflux;
1452-15-9

thiazole-4-carbonitrile

95-54-5

1,2-diamino-benzene

50-81-7

ascorbic acid

71-36-3

butan-1-ol

148-79-8

thiabendazole

Conditions
ConditionsYield
With methanesulfonic acid In water87.1%
With acetic acid In water75.4%
3364-80-5

1,3-thiazole-4-carbaldehyde

95-54-5

1,2-diamino-benzene

148-79-8

thiabendazole

Conditions
ConditionsYield
With sodium metabisulfite In N,N-dimethyl-formamide at 120℃;85%
Stage #1: 1,3-thiazole-4-carbaldehyde; 1,2-diamino-benzene In N,N-dimethyl-formamide for 0.0833333h; Inert atmosphere;
Stage #2: With sodium metabisulfite In N,N-dimethyl-formamide at 20℃; Inert atmosphere;
With sodium disulfite In N,N-dimethyl-formamide at 20℃; for 8h;
With sodium metabisulfite In N,N-dimethyl-formamide at 120℃;
With sodium metabisulfite In N,N-dimethyl-formamide for 6h;
1452-15-9

thiazole-4-carbonitrile

5329-14-6

aminosulfonic acid

95-54-5

1,2-diamino-benzene

50-81-7

ascorbic acid

71-36-3

butan-1-ol

148-79-8

thiabendazole

Conditions
ConditionsYield
In water75.7%
1452-15-9

thiazole-4-carbonitrile

tin(II)chloride dihydrate

95-54-5

1,2-diamino-benzene

50-81-7

ascorbic acid

71-36-3

butan-1-ol

148-79-8

thiabendazole

Conditions
ConditionsYield
In water74.5%

(E)-N-phenyl-N′-((4-(trifluoromethyl)benzoyl)oxy)thiazole-4-carboximidamide

148-79-8

thiabendazole

Conditions
ConditionsYield
With [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate In tert-butyl methyl ether at 20℃; for 36h; Schlenk technique; Sealed tube; Inert atmosphere;40%

C18H12F3N3O2S

148-79-8

thiabendazole

Conditions
ConditionsYield
With [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate In tert-butyl methyl ether at 20℃; for 36h; Schlenk technique; Sealed tube;40%

Thiabendazole Consensus Reports

EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory.

Thiabendazole Specification

Thiabendazole, with the IUPAC Name of 4-(1H-Benzimidazol-2-yl)-1,3-thiazole, is one kind of light yellow powder. This chemical belongs to the Product Categories which include Xanthones; Heterocyclic Compounds; FUNGICIDE; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals; Sulfur & Selenium Compounds; API's. With the CAS NO. 148-79-8, Thiabendazole is a systemic benzimidazole fungicide.

Physical properties about Thiabendazole are: (1)ACD/LogP: 2.47; (2)ACD/LogD (pH 5.5): 2.46; (3)ACD/LogD (pH 7.4): 2.47; (4)ACD/BCF (pH 5.5): 43.36; (5)ACD/BCF (pH 7.4): 44.36; (6)ACD/KOC (pH 5.5): 513.56; (7)ACD/KOC (pH 7.4): 525.39; (8)#H bond acceptors: 3; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 1; (11)Index of Refraction: 1.74; (12)Molar Refractivity: 57.687 cm3; (13)Molar Volume: 143.083 cm3; (14)Polarizability: 22.869 10-24cm3; (15)Surface Tension: 71.1259994506836 dyne/cm; (16)Density: 1.407 g/cm3; (17)Flash Point: 226.212 °C ; (18)Enthalpy of Vaporization: 70.403 kJ/mol; (19)Boiling Point: 445.951 °C at 760 mmHg

Uses of Thiabendazole: Thiabendazole is used primarily to control mold, blight, and other fungally caused diseases in fruits (e.g. oranges) and vegetables; it is also used as a prophylactic treatment for Dutch Elm disease and used in treatment of Aspergillus has been reported.As an antiparasitic, it is able to control roundworms, hookworms, and other helminth species which attack wild animals, livestock and humans.Medicinally, Thiabendazole is also a chelating agent, which means that it is used medicinally to bind metals in cases of metal poisoning, such as lead poisoning, mercury poisoning or antimony poisoning. In dogs and cats thiabendazole is also used to treat ear infections. Thiabendazole is also used as a food additive, a preservative with E number E233. For example, it is applied to bananas to ensure freshness, and is a common ingredient in the waxes applied to the skin of citrus fruits.

When you are using this chemical, please be cautious about it as the following:
1. This material and/or its container must be disposed of as hazardous waste;
2. Avoid release to the environment. Refer to special instructions safety data sheet;
3. Wear suitable protective clothing;
4. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;

You can still convert the following datas into molecular structure:
(1)InChI=1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13);
(2)InChIKey=WJCNZQLZVWNLKY-UHFFFAOYSA-N;
(3)Smilesc1(c2cscn2)[nH]c2ccccc2n1;

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LD50 oral 4gm/kg (4000mg/kg)   Veterinarno-Meditsinski Nauki. Veterinary Science. Vol. 19(3), Pg. 99, 1982.
domestic animals - goat/sheep LD50 oral 400mg/kg (400mg/kg)   Veterinarno-Meditsinski Nauki. Veterinary Science. Vol. 19(3), Pg. 99, 1982.
man TDLo oral 47619ug/kg/1D (47.619mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pediatrics. Vol. 102, Pg. 317, 1983.
 
mouse LD50 oral 1300mg/kg (1300mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 55(10), Pg. 28, 1990.
rabbit LD50 oral 3850mg/kg (3850mg/kg)   "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976.
rat LD50 oral 2080mg/kg (2080mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. Vol. 36(1-4), Pg. 10, 1989.

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