Phe178 has also been proposed to have an acid-base catalytic role in the reaction mechanism of aristolochene synthase. During the catalytic cycle, FPP undergoes a series of cyclization reactions to form aristolochene. Phe178 may participate in these reactions by acting as an acid or a base, helping to facilitate the formation of certain intermediates and the eventual production of aristolochene. This acid-base catalysis is an essential aspect of the enzyme's function in converting FPP into the desired product.
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(S)-(-)-germacrene A
(S)-(-)-germacrene A
[2,2,2-Trifluoro-1-(trifluoromethyl)ethyl]benzene
