Thermodynamic control focuses on the stability and energy differences between different products. Reactions under thermodynamic control aim to produce the most stable product, which often corresponds to the lowest energy state. In the context of complex molecule synthesis, thermodynamic control may be used to select the most stable isomer or stereoisomer among several possible products. Achieving thermodynamic control can involve manipulating reaction conditions, such as temperature and time, to allow equilibration to occur and favor the formation of the most thermodynamically stable products.
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