Desilylation refers to the removal of a silyl group from a molecule. In the context of β-hydroxysilanes, this typically involves the removal of a silicon atom attached to the β-carbon (the carbon adjacent to the hydroxyl group). The reaction is often carried out using a suitable desilylating agent, such as fluoride ions (F^-), tetrabutylammonium fluoride (TBAF), or other fluoride sources. These agents can effectively cleave the silicon-oxygen bond in the presence of a hydroxyl group. The presence of substituents on silicon can influence the reactivity of the silicon-oxygen bond. Electron-withdrawing groups on silicon may stabilize the silyl group and make desilylation less favorable, while electron-donating groups may enhance the reactivity.
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Silane, 1-cyclohexen-1-yldimethyl-
4-<(tert-butyldimethylsilyl)oxy>-3-methoxybenzyl alcohol
2-(trimethylsilyl)ethyl 3,3-difluoro-2-[(4-methoxyphenyl)imino]-5-hexenoate
1,4-di-(o-tolyl)buta-1,3-diyne
2-Piperidinethione, 1-[(trimethylsilyl)methyl]-
