Hypertension

A medical condition characterized by abnormally high blood pressure.

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Synthesis Pharmacological evaluation Column chromatography Melting point Yield Bioassay Chiral center Chromatography Mass spectrometry (MS) IC50 Pharmacophore Ketone NMR (nuclear magnetic resonance) Purification In vitro Testing In Vivo Testing Lead Optimization Docking Studies Structure-Activity Relationship (SAR) Reaction Optimization Spectroscopic Analysis Hybrid Molecules In vitro assay In vivo assay Substituent antihypertensive 8-substituted Antihypertensive Activity Bioisostere ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) Spirocyclic Compound

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