Synthesis and antihypertensive activity of a series of 8-substituted 1-oxa-3,8-diazaspiro[4,5]decan-2-ones

DOI: 10.1021/jm00143a012

Source and publish data:

Journal of Medicinal Chemistry p. 1320 - 1328 (1981)

Update date:2022-08-05

Topics: Synthesis   Pharmacological evaluation   Melting point   Yield   Bioassay   Chromatography   IC50   Ketone   Purification   In vitro Testing   In Vivo Testing   Structure-Activity Relationship (SAR)   Reaction Optimization   Spectroscopic Analysis   Substituent   8-substituted   Antihypertensive Activity   Hypertension   Spirocyclic Compound  

Authors:

Caroon

Clark

Kluge

Nelson

Strosberg

Unger

Michel

Whiting