Safety and Toxicity Studies

Synthesis Optimization Photolysis 5′-32P-labeled duplex H2O/CH3CN mixture Cross-link formation Ethanol precipitation DPAGE Maxam-Gilbert reactions Exocyclic amine Minor groove Congeners X-ray structure Spectroscopic and analytical data Retrosynthetic analysis Purification and characterization In vitro Testing Biological Assays Structure-Activity Relationship (SAR) Studies Clinical Trials In Vivo Testing Formulation Development Lead Compound Identification Pharmacokinetic Studies Target Identification and Validation Compound Design Synthesis of Compounds Preclinical Development Structural Elucidation DNA Interaction Biological Studies Mitosene Progenitor Design Synthesis of the Mitosene Progenitor DNA Cross-Linking Quantitative Structure-Activity Relationship (QSAR) Studies Formulation and Preclinical Testing