Once designed, suramin analogues are synthesized and subjected to extensive in vitro and in vivo testing to evaluate their efficacy and safety. Promising analogues are then further developed for clinical trials.
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N,N'-bis(3-aminophenyl)urea
6-anilino-quinazolino[4,3-b]quinazolin-8-one
L-Leucine, N-[[3-oxo-2-(phenylmethyl)-3H-pyrrolizin-5-yl]carbonyl]-, methyl ester
5-(2-furylmethylene)imidazolidine-2,4-dione
