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| CAS No.: | 122-52-1 |
|---|---|
| Name: | Triethyl phosphite |
| Article Data: | 127 |
| Molecular Structure: | |
|
|
|
| Formula: | C6H15O3P |
| Molecular Weight: | 166.157 |
| Synonyms: | Ethylphosphite, (EtO)3P (7CI);Ethyl phosphite, Et3PO3 (4CI);NSC 5284;Triethoxyphosphine;Tris(ethoxy)phosphine; |
| EINECS: | 204-552-5 |
| Density: | 0.989 |
| Melting Point: | -112°C |
| Boiling Point: | 159.8 °C at 760 mmHg |
| Flash Point: | 54.1 °C |
| Solubility: | slightly soluble in water |
| Appearance: | clear colorless liquid |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 10-22-36/37/38-20/22 |
| Safety: | 16-26-36 |
| Transport Information: | UN 2323 3/PG 3 |
| PSA: | 41.28000 |
| LogP: | 2.32280 |
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| Conditions | Yield |
|---|---|
| With ammonia; N,N-dimethyl-aniline; phosphorus trichloride In 1,2-dichloro-benzene at 10℃; pH=6 - 9; Temperature; pH-value; | 99.71% |
| With triethanolamine; phosphorus trichloride In toluene at 15 - 50℃; for 2.7h; Reagent/catalyst; | 96% |
| With Tri-n-octylamine; sodium carbonate; triethylamine; phosphorus trichloride In hexane at 5℃; for 2h; Temperature; Reagent/catalyst; | 83.7% |
- 109-83-1
(2-hydroxyethyl)(methyl)amine
- 589-57-1
diethyl phosphorylchloridite
A
- 7077-42-1
2-ethoxy-3-methyl-1,3,2-oxazaphospholidine
B
- 122-52-1
triethyl phosphite
| Conditions | Yield |
|---|---|
| at 10 - 15℃; | A 67% B 92% |
- 21646-99-1
diphosphorous acid tetraethyl ester
- 122-51-0
orthoformic acid triethyl ester
A
- 65600-72-8
ethyl P-(diethoxymethyl)phosphonite
B
- 122-52-1
triethyl phosphite
| Conditions | Yield |
|---|---|
| With boron trifluoride diethyl etherate at 20℃; for 3h; argon atmosphere; | A 89% B 69% |
- 64-17-5
ethanol
- 96529-96-3
diethoxyphosphino ethyl cyclohexylphosphonate
A
- 4546-15-0
ethyl hydrogen cyclohexylphosphonate
B
- 122-52-1
triethyl phosphite
| Conditions | Yield |
|---|---|
| In benzene for 1h; Heating; argon atmosphere; | A 0.93 g B 87% |
- 64-17-5
ethanol
- 127088-86-2
S-(2-cyanoethyl) N,N,N',N'-tetraisopropylthiophosphorodiamidite
C
- 122-52-1
triethyl phosphite
| Conditions | Yield |
|---|---|
| With 1H-tetrazole In acetonitrile at 25℃; for 0.166667h; | A 5% B 85% C 7% |
| With 1H-tetrazole In acetonitrile at 25℃; for 0.166667h; | A 22% B 18% C 60% |
- 589-57-1
diethyl phosphorylchloridite
- 7077-42-1
2-ethoxy-3-methyl-1,3,2-oxazaphospholidine
A
- 22082-71-9
2-chloro-3-methyl-1,3,2-oxazaphospholidine
B
- 122-52-1
triethyl phosphite
| Conditions | Yield |
|---|---|
| at 100℃; for 1h; | A 83% B 57% |
- 1498-42-6
phosphorodichloridous acid ethyl ester
- 64-17-5
ethanol
A
- 589-57-1
diethyl phosphorylchloridite
B
- 122-52-1
triethyl phosphite
| Conditions | Yield |
|---|---|
| With triethylamine In toluene | A 82% B 18% |
- 64-17-5
ethanol
- 79948-06-4
O,O-diethyl-N-butyl-N-isobutenyl aminophosphite
A
- 6898-75-5
N-isobutylidenebutylamine
B
- 122-52-1
triethyl phosphite
| Conditions | Yield |
|---|---|
| at 20℃; for 1440h; | A 72.5% B 81.7% |
- 79948-06-4
O,O-diethyl-N-butyl-N-isobutenyl aminophosphite
A
- 6898-75-5
N-isobutylidenebutylamine
B
- 122-52-1
triethyl phosphite
| Conditions | Yield |
|---|---|
| With ethanol at 20℃; for 1440h; further reagents; | A 72.5% B 81.7% |
- 64-17-5
ethanol
- 73868-59-4
2-diethylamido-4-oxo-1,3-dimethyl-1,3,2-diazaphosphorinane
- 122-52-1
triethyl phosphite
| Conditions | Yield |
|---|---|
| at 70℃; for 3h; | 81% |
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- Total:24 Page 1 of 1 1
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Specification
The Triethyl phosphite is an organic compound with the formula C6H15O3P. The IUPAC name of this chemical is triethyl phosphite. With the CAS registry number 122-52-1, it is also named as Ethyl phosphite. The product's categories are Phosphonate Chemicals; Phosphite Ligands; Catalysis and Inorganic Chemistry; Phosphorus Compounds. Besides, it is a clear colorless liquid, which should be stored in cool and ventilated place.
The Triethyl phosphite is used as a plastic stabilizer and plasticizer, and also used as medicine, pesticide intermediates. It is used to produce analgesic pizotifen, viagra and other pesticides fenitrothion, and also used as plasticizers, stabilizers, lubricants and grease additives.
Physical properties about Triethyl phosphite are: (1)ACD/LogP: 0.67; (2)ACD/LogD (pH 5.5): 0.67; (3)ACD/LogD (pH 7.4): 0.67; (4)ACD/BCF (pH 5.5): 1.89; (5)ACD/BCF (pH 7.4): 1.89; (6)ACD/KOC (pH 5.5): 54.86; (7)ACD/KOC (pH 7.4): 54.86; (8)#H bond acceptors: 3; (9)#Freely Rotating Bonds: 6; (10)Polar Surface Area: 41.28 Å2; (11)Flash Point: 54.1 °C; (12)Enthalpy of Vaporization: 38.01 kJ/mol; (13)Boiling Point: 159.8 °C at 760 mmHg; (14)Vapour Pressure: 3.19 mmHg at 25°C.
Preparation: this chemical can be prepared by ethanol, phosphorus trichloride and ammonia. This reaction will need reagent Xylene.
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When you are using this chemical, please be cautious about it as the following:
It is flammable and harmful by inhalation and if swallowed. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, this chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable protective clothing and keep away from sources of ignition - No smoking.
You can still convert the following datas into molecular structure:
(1)SMILES: O(P(OCC)OCC)CC
(2)InChI: InChI=1/C6H15O3P/c1-4-7-10(8-5-2)9-6-3/h4-6H2,1-3H3
(3)InChIKey: BDZBKCUKTQZUTL-UHFFFAOYAP
(4)Std. InChI: InChI=1S/C6H15O3P/c1-4-7-10(8-5-2)9-6-3/h4-6H2,1-3H3
(5)Std. InChIKey: BDZBKCUKTQZUTL-UHFFFAOYSA-N
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LC50 | inhalation | 6203mg/m3/6H (6203mg/m3) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 218, 1992. |
| mouse | LD | intraperitoneal | > 500mg/kg (500mg/kg) | "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 5, Pg. 286, 1953. | |
| mouse | LD50 | oral | 3720mg/kg (3720mg/kg) | BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 218, 1992. |
| rabbit | LD50 | skin | 2800mg/kg (2800mg/kg) | Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 218, 1992. | |
| rat | LC50 | inhalation | 11063mg/m3/6H (11063mg/m3) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 218, 1992. |
| rat | LD50 | oral | 1840mg/kg (1840mg/kg) | BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 218, 1992. |