Products Categories
| CAS No.: | 16188-55-9 |
|---|---|
| Name: | 4-Methylthiophenylacetic acid |
| Article Data: | 12 |
| Molecular Structure: | |
|
|
|
| Formula: | C9H10 O2 S |
| Molecular Weight: | 182.243 |
| Synonyms: | Acetic acid,[p-(methylthio)phenyl]- (6CI,7CI,8CI); (4-Methylsulfanylphenyl)acetic acid;2-[4-(Methylthio)phenyl]acetic acid; 4-(Methylthio)phenylacetic acid;[p-(Methylthio)phenyl]acetic acid |
| Density: | 1.16g/cm3 |
| Melting Point: | 97-98 ºC |
| Boiling Point: | 274.2°Cat760mmHg |
| Flash Point: | 125.4°C |
| Appearance: | Cream crystalline powder |
| Hazard Symbols: |
|
| Risk Codes: | R36/37/38 |
| Safety: | S26;S36 |
| PSA: | 62.60000 |
| LogP: | 2.03560 |
- 483366-12-7(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
- 173606-50-3BOC-10-AMINODECANOIC ACID
- 361456-36-2METHYL (R)-(+)-ISOCYANATO-3-PHENYLPROPI&
- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 50288-62-5threo-Phenyl-2-piperidyl acetamide
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 47087-37-6Z-D-Glu-OMe
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 211914-50-0N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-(2-pyridinyl)-beta-alanine ethyl ester hydrochloride
- 53066-99-2
2-(4-(methylthio)phenyl)-2-oxoacetic acid
- 16188-55-9
2-(4-(methylthio)phenyl)acetic acid
| Conditions | Yield |
|---|---|
| Stage #1: 2-(4-(methylthio)phenyl)-2-oxoacetic acid With sodium iodide In dichloromethane at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: With chloro-trimethyl-silane In dichloromethane at 20℃; for 2h; Inert atmosphere; regioselective reaction; | 91% |
| Stage #1: 2-(4-(methylthio)phenyl)-2-oxoacetic acid With sodium hydroxide; hydrazine In water at 75℃; for 120h; Wolff-Kishner Reduction; Heating / reflux; Stage #2: With hydrogenchloride In water pH=1.5; |
- 38746-92-8
2-[4-(methylsulfanyl)phenyl]acetonitrile
- 16188-55-9
2-(4-(methylthio)phenyl)acetic acid
| Conditions | Yield |
|---|---|
| Stage #1: 2-[4-(methylsulfanyl)phenyl]acetonitrile With potassium hydroxide; water for 8h; Reflux; Stage #2: With hydrogenchloride; water at 20℃; | 82% |
| With sodium hydroxide In ethylene glycol; ethyl acetate | |
| With sulfuric acid; water for 1h; Reflux; |
- 1878-66-6
4-chlorophenylacetic Acid
- 5188-07-8
sodium thiomethoxide
- 16188-55-9
2-(4-(methylthio)phenyl)acetic acid
| Conditions | Yield |
|---|---|
| With copper(I) bromide In N,N-dimethyl-formamide at 130℃; for 24h; Inert atmosphere; | 79.3% |
- 5188-07-8
sodium thiomethoxide
- 1878-68-8
2-(4-bromophenyl)-acetic acid
- 16188-55-9
2-(4-(methylthio)phenyl)acetic acid
| Conditions | Yield |
|---|---|
| With copper(I) bromide In N,N-dimethyl-formamide at 130℃; Inert atmosphere; | 76.1% |
- 1778-09-2
4-(Methylthio)acetophenone
- 16188-55-9
2-(4-(methylthio)phenyl)acetic acid
| Conditions | Yield |
|---|---|
| With morpholine; sulfur for 20h; Heating; | 53% |
| Stage #1: 4-(Methylthio)acetophenone With morpholine; sulfur at 130℃; for 48h; Willgerodt reaction; Stage #2: With sodium hydroxide; water at 130℃; for 24h; Stage #3: With hydrogenchloride In water |
- 1798-06-7
(4-iodophenyl)acetic acid
- 4856-13-7
cuprous methylmercaptide
- 16188-55-9
2-(4-(methylthio)phenyl)acetic acid
| Conditions | Yield |
|---|---|
| With quinoline at 200℃; |
| Conditions | Yield |
|---|---|
| Erhitzen des Reaktionsgemisches mit wss. HCl; |
- 16188-55-9
2-(4-(methylthio)phenyl)acetic acid
| Conditions | Yield |
|---|---|
| With morpholine; sulfur Erhitzen des Reaktionsgemisches mit wss. Salzsaeure; |
- 100-68-5
methyl-phenyl-thioether
- 16188-55-9
2-(4-(methylthio)phenyl)acetic acid
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 90 percent / AlCl3 / CHCl3 / 0 - 5 °C 2: 53 percent / S8, Morpholin / 20 h / Heating View Scheme |
- 67-56-1
methanol
- 16188-55-9
2-(4-(methylthio)phenyl)acetic acid
- 70290-37-8
(4-methylsulfanyl-phenyl)-acetic acid methyl ester
| Conditions | Yield |
|---|---|
| With sulfuric acid at 50℃; for 16h; | 100% |
| With thionyl chloride at 0 - 20℃; for 48h; | 100% |
| With sulfuric acid for 19h; Heating / reflux; | 98% |
| With sulfuric acid In benzene at 0 - 80℃; for 16h; Inert atmosphere; | 83.1% |
| With hydrogenchloride |
What can I do for you?
Get Best Price
Chemistry
.jpg)
Molecular Formula: C9H10O2S
Molecular Weight: 182.24 g/mol
Canonical SMILES: O=C(O)Cc1ccc(SC)cc1
InChI: InChI=1/C9H10O2S/c1-12-8-4-2-7(3-5-8)6-9(10)11/h2-5H,6H2,1H3,(H,10,11)
Mol File: 16188-55-9.mol
Product Categories: C9;Carbonyl Compounds; Carboxylic Acids
Nominal Mass: 182
Average Mass: 182.2395
Monoisotopic Mass: 182.04015
H bond acceptors: 2
H bond donors: 1
Freely Rotating Bonds: 3
Polar Surface Area: 51.6
Index of Refraction: 1.596
Molar Refractivity: 50.29 cm3
Molar Volume: 147.7 cm3
Polarizability: 19.93×10-24cm3
Surface Tension: 51.9 dyne/cm
Density: 1.23 g/cm3
Flash Point: 157.9 °C
Enthalpy of Vaporization: 61.29 kJ/mol
Boiling Point: 337.4 °C at 760 mmHg
Melting Point: 97-98 °C(lit.)
Vapour Pressure of 4-Methylthiophenylacetic acid (CAS NO.16188-55-9): 4.1E-05 mmHg at 25 °C
Safety Profile
Hazard Codes: 
Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
WGK Germany of 4-Methylthiophenylacetic acid (CAS NO.16188-55-9): 3
Specification
4-Methylthiophenylacetic acid (CAS NO.16188-55-9), its synonyms are (4-Methylsulfanyl-phenyl)-cetic acid ; 2-(4-(methylthio)phenyl)acetic acid ; 4-(Methylthio)benzeneacetic acid ; 4-(Methylthio)phenylacetic acid,98% . It is a cream crystalline powder.