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| CAS No.: | 22245-83-6 |
|---|---|
| Name: | 2-Hydroxy-3-trifluoromethylpyridine |
| Article Data: | 10 |
| Cas Database | |
| Molecular Structure: | |
|
|
|
| Formula: | C6H4F3NO |
| Molecular Weight: | 163.099 |
| Synonyms: | LDP51:2-Hydroxy-3- Trifluoromethyl Pyridine;2-Hydroxy-3-trifluoromethyl -pyridine;2-Hydroxy-3-trifluoromethyl pyridine;2-Hydroxy-3- Trifluoromethyl Pyridine; |
| EINECS: | 671-273-7 |
| Density: | 1.398 g/cm3 |
| Melting Point: | 150-153 ºC |
| Boiling Point: | 223.7 ºC at 760 mmHg |
| Flash Point: | 89.1 ºC |
| Hazard Symbols: |
 Xi, Xn
|
| Risk Codes: | 36/37/38-65-20/21/22-20/21 |
| Safety: | 26-36/37/39 |
| PSA: | 33.12000 |
| LogP: | 1.80600 |
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- 22246-00-06-AMINO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
- 22246-04-41(2H)-Isoquinolinone,3,4-dihydro-7-methoxy-
- 22246-07-72(1H)-Quinolinone,7-amino-3,4-dihydro-
- 22246-12-41(2H)-Isoquinolinone,3,4-dihydro-6-methoxy-
- 22246-13-52(1H)-Quinolinone,6-amino-3,4-dihydro-
- 22246-18-03,4-Dihydro-7-hydroxy-2(1H)-quinolinone
- 22246-26-01(2H)-Naphthalenone,3,4-dihydro-6-nitro-
- 22246-45-32H-1-Benzazepin-2-one, 1,3,4,5-tetrahydro-7-nitro-
- 65753-47-1
2-chloro-3-trifluoromethyl-pyridine
- 22245-83-6
3-(trifluoromethyl)pyridin-2-ol
| Conditions | Yield |
|---|---|
| With potassium hydroxide In tert-butyl alcohol for 10h; Heating; | 73% |
| Stage #1: 2-chloro-3-trifluoromethyl-pyridine With potassium hydroxide In tert-butyl alcohol at 20 - 90℃; Stage #2: With acetic acid In tert-butyl alcohol | |
| Multi-step reaction with 3 steps 1: hydrogen fluoride / 48 h / 130 °C / 60006 Torr / Autoclave 2: ammonia / water / 10 h / 130 °C / 22502.3 Torr 3: sodium nitrite; hydrogenchloride / water / 3 h / 0 °C View Scheme |
| Conditions | Yield |
|---|---|
| With ferrocene; dihydrogen peroxide; dimethyl sulfoxide In water at 40 - 50℃; for 0.333333h; | 50% |
| With ferrocene; dihydrogen peroxide In water; dimethyl sulfoxide | 68 %Spectr. |
- 183610-70-0
2-amino-3-trifluoromethylpyridine
- 22245-83-6
3-(trifluoromethyl)pyridin-2-ol
| Conditions | Yield |
|---|---|
| With hydrogenchloride; sodium nitrite In water at 0℃; for 3h; Temperature; |
- 22245-83-6
3-(trifluoromethyl)pyridin-2-ol
| Conditions | Yield |
|---|---|
| With [Rh(cod)(CI)(CAACMe2)]; hydrogen In hexane at 40℃; for 24h; Molecular sieve; diastereoselective reaction; | 98% |
- 22245-83-6
3-(trifluoromethyl)pyridin-2-ol
| Conditions | Yield |
|---|---|
| With bromine In methanol at 20℃; for 22h; | 95% |
| With bromine In methanol; ethyl acetate | |
| With N-Bromosuccinimide In tetrahydrofuran at 20℃; for 4h; | |
| With N-Bromosuccinimide In tetrahydrofuran at 20℃; | |
| With N-Bromosuccinimide In tetrahydrofuran at 20℃; |
- 22245-83-6
3-(trifluoromethyl)pyridin-2-ol
- 99368-66-8
2-hydroxyl-5-nitro-3-(trifluoromethyl)pyridine
| Conditions | Yield |
|---|---|
| With sulfuric acid; nitric acid at -10 - 40℃; for 6h; | 94% |
| With sulfuric acid; nitric acid at 60℃; for 21.5h; Temperature; Cooling with ice; | 78% |
| With sulfuric acid; nitric acid at 20℃; for 4h; Cooling with ice; | 74.5% |
- 22245-83-6
3-(trifluoromethyl)pyridin-2-ol
| Conditions | Yield |
|---|---|
| With silver nitrate; sodium hydroxide In water for 0.5h; Inert atmosphere; | 93% |
- 22245-83-6
3-(trifluoromethyl)pyridin-2-ol
- 887707-23-5
2-hydroxy-3-trifluoromethyl-5-(iodo)pyridine
| Conditions | Yield |
|---|---|
| With N-iodo-succinimide; acetic acid In acetonitrile at 65℃; for 5h; Industrial scale; | 86% |
| With N-iodo-succinimide In N,N-dimethyl-formamide; acetonitrile at 80℃; for 2h; | 81% |
| With N-iodo-succinimide In N,N-dimethyl-formamide at 80℃; for 2h; | 80% |
- 22245-83-6
3-(trifluoromethyl)pyridin-2-ol
- 781-03-3
isopentenyl tosylate
| Conditions | Yield |
|---|---|
| With potassium carbonate In acetonitrile at 70℃; for 12h; Inert atmosphere; | 85% |
- 22245-83-6
3-(trifluoromethyl)pyridin-2-ol
- 1174132-90-1
methanesulfonic acid 5-chloro-4-(2,3,4,5-tetrahydro-pyran-2-yloxymethyl)-pyridin-3-ylmethyl ester
- 1174132-93-4
1-(5-chloro-4-hydroxymethyl-pyridin-3-ylmethyl)-3-trifluoromethyl-1H-pyridin-2-one trifluoroacetate
| Conditions | Yield |
|---|---|
| With sodium hydride In parafine; N,N-dimethyl-formamide at 20℃; for 2h; | 70% |
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Chemistry
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IUPAC Name: 3-(Trifluoromethyl)-1H-pyridin-2-one
Molecular Formula: C6H4F3NO
Molecular Weight: 163.10 g/mol
SMILES: FC(F)(F)C\1=C\C=C/NC/1=O
InChI: InChI=1/C6H4F3NO/c7-6(8,9)4-2-1-3-10-5(4)11/h1-3H,(H,10,11)
Product Categories: blocks; FluoroCompounds; Pyridines; Pyridine
Index of Refraction: 1.436
Molar Refractivity: 30.52 cm3
Molar Volume: 116.6 cm3
Polarizability: 12.1×10-24 cm3
Surface Tension: 28.4 dyne/cm
Density: 1.398 g/cm3
Flash Point: 89.1 °C
Enthalpy of Vaporization: 46.02 kJ/mol
Boiling Point: 223.7 °C at 760 mmHg
Melting Point: 150-153 °C
Vapour Pressure of 2-Hydroxy-3-trifluoromethylpyridine (CAS NO.22245-83-6): 0.0947 mmHg at 25 °C
Production
The productions of 2-hydroxy-3-trifluoromethylpyridine include blocks,FluoroCompounds,Pyridines,Pyridine.
Safety Profile
Hazard Codes: 
Xi,
Xn
Risk Statements: 36/37/38-65-20/21/22-20/21
R36/37/38:Irritating to eyes, respiratory system and skin.
R65:Harmful: may cause lung damage if swallowed.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R20/21:Harmful by inhalation and in contact with skin.
Safety Statements: 26-36/37/39-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S36:Wear suitable protective clothing.
Hazard Note: Irritant
HazardClass of 2-Hydroxy-3-trifluoromethylpyridine (CAS NO.22245-83-6): IRRITANT
Specification
2-Hydroxy-3-trifluoromethylpyridine (CAS NO.22245-83-6), its Synonyms are 3-(Trifluoromethyl)pyridin-2-one ; 3-Trifluoromethyl-pyridin-2-ol ; 2-Hydroxy-3-(trifluoromethyl)pyridine 97% .