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CAS No.: | 4897-50-1 |
---|---|
Name: | 4-Piperidinopiperidine |
Article Data: | 6 |
Molecular Structure: | |
Formula: | C10H20N2 |
Molecular Weight: | 168.282 |
Synonyms: | 1,4-Bipiperidyl;1,4'-bipiperidine;1-(3,4,5,6-tetrahydro-2H-pyridin-4-yl)-3,4,5,6-tetrahydro-2H-pyridine;4-(1-piperidinyl)piperidine;[1,4']Bipiperidinyl;4-(1-Piperidino)piperidine;1-(4-piperidyl)piperidine; |
EINECS: | 225-522-8 |
Density: | 0.969 g/cm3 |
Melting Point: | 64-66 °C(lit.) |
Boiling Point: | 251.4 °C at 760 mmHg |
Flash Point: | 99.9 °C |
Appearance: | light yellow to yellow-brown crystalline solid |
Hazard Symbols: | Xi |
Risk Codes: | 36/37/38 |
Safety: | 24/25-26-36 |
PSA: | 15.27000 |
LogP: | 1.49100 |
Conditions | Yield |
---|---|
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 0 - 20℃; for 16h; | 80% |
4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine
A
4-piperidinopiperidin
Conditions | Yield |
---|---|
A n/a B 35% |
irinotecan
A
4-piperidinopiperidin
B
7-ethyl-10-hydroxycamptothecin
Conditions | Yield |
---|---|
With carboxylesterase at 37℃; for 0.0833333h; pH=7.4; |
[1,4']bipiperidinyl-1'-carboxylic acid (4-bromo-phenyl)amide
A
4-piperidinopiperidin
C
C14H14N2O
D
4-bromo-aniline
Conditions | Yield |
---|---|
Suzuki-Miyaura Coupling; |
N-tert-butyloxycarbonylpiperidin-4-one
4-piperidinopiperidin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 0 - 20 °C 2: hydrogenchloride / methanol / 12 h / 40 °C View Scheme |
tert-butyl 1,4’-bipiperidine-1’-carboxylate
4-piperidinopiperidin
Conditions | Yield |
---|---|
With hydrogenchloride In methanol at 40℃; for 12h; | 2.04 g |
4-piperidinopiperidin
5-fluoro-2-nitroaniline
2-nitro-5-(4-(piperidin-1-yl)piperidin-1-yl)benzenamine
Conditions | Yield |
---|---|
With triethylamine In 1-methyl-pyrrolidin-2-one at 100℃; for 2.5h; | 100% |
With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 120℃; for 4h; | 75% |
4-piperidinopiperidin
[Bis(methylthio)methylene]malononitrile
[(methylthio)(4-piperidinopiperidino)methylene]malononitrile
Conditions | Yield |
---|---|
In tetrahydrofuran at 0 - 20℃; for 0.25h; | 100% |
4-piperidinopiperidin
2-tert-butyloxycarbonylamino-3-(3,4-dichlorophenyl)propionic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide | 100% |
Conditions | Yield |
---|---|
100% |
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The 4-Piperidinopiperidine, with the CAS registry number 4897-50-1, is also known as 1,4'-Bipiperidin. It belongs to the product categories of Nitrogen Cyclic Compounds; Pharmaceutical Intermediates; Heterocycles; Piperidine; Heterocyclic Compounds; Piperidine Series; Piperidines. Its EINECS registry number is 225-522-8. This chemical's molecular formula is C10H20N2 and molecular weight is 168.2792. Its IUPAC name is called 1-piperidin-4-ylpiperidine. What's more, the product should be sealed and stored in cool and dry place.
Physical properties of 4-Piperidinopiperidine: (1)ACD/LogP: 1.53; (2)ACD/LogD (pH 5.5): -2.57; (3)ACD/LogD (pH 7.4): -2.18; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 2; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 1; (11)Index of Refraction: 1.5; (12)Molar Refractivity: 51.07 cm3; (13)Molar Volume: 173.6 cm3; (14)Surface Tension: 35.5 dyne/cm; (15)Density: 0.969 g/cm3; (16)Flash Point: 99.9 °C; (17)Enthalpy of Vaporization: 48.88 kJ/mol; (18)Boiling Point: 251.4 °C at 760 mmHg; (19)Vapour Pressure: 0.0205 mmHg at 25°C.
Uses of 4-Piperidinopiperidine: it can be used to produce 4-Oxo-4-phenyl-2-(4-piperidinopiperidino)-butansaeure with 4-oxo-4-phenyl-but-2-enoic acid. This reaction will need solvents toluene and ethanol. The yield is about 68%.
When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing.
You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C1CCN(CC1)C2CCNCC2
(2)InChI: InChI=1S/C10H20N2/c1-2-8-12(9-3-1)10-4-6-11-7-5-10/h10-11H,1-9H2
(3)InChIKey: QDVBKXJMLILLLB-UHFFFAOYSA-N