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| CAS No.: | 498-95-3 |
|---|---|
| Name: | Nipecotic acid |
| Molecular Structure: | |
|
|
|
| Formula: | C6H11NO2 |
| Molecular Weight: | 129.159 |
| Synonyms: | 3-Piperidinecarboxylicacid;Nipecoticacid (6CI,7CI,8CI);3-Carboxypiperidine;DL-Nipecotic acid;Hexahydronicotinic acid;3-Piperidinecarboxylic Acid;Piperidine-3-carboxylic acid;H-DL-Nip-OH; |
| EINECS: | 207-873-9 |
| Density: | 1.125 g/cm3 |
| Melting Point: | 261 °C (dec.)(lit.) |
| Boiling Point: | 265.8 °C at 760 mmHg |
| Flash Point: | 114.5 °C |
| Solubility: | Soluble in water |
| Appearance: | off-white to pale yellow-beige powder |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-36-37/39 |
| PSA: | 49.33000 |
| LogP: | 0.39940 |
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| Conditions | Yield |
|---|---|
| With hydrogen In water at 120℃; under 11251.1 Torr; for 1h; | 100% |
| Conditions | Yield |
|---|---|
| With platinum(IV) oxide; hydrogen In ethanol at 80℃; under 6205.94 Torr; for 0.666667h; Microwave irradiation; | 98% |
| With ethanol; sodium | |
| With hydrogenchloride; platinum Hydrogenation; |
- 141943-03-5
N-benzylnipecotic acid benzyl ester
A
- 141943-04-6
1-benzylpiperidine-3-carboxylic acid
B
- 498-95-3
nipecotic acid
| Conditions | Yield |
|---|---|
| With cyclohexa-1,4-diene; hydrogen; palladium on activated charcoal In ethanol for 0.166667h; Ambient temperature; | A 63% B 30% |
| Conditions | Yield |
|---|---|
| With Ki In ethyl acetate; acetone | 55% |
| Conditions | Yield |
|---|---|
| With (S)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyldicyclohexylphosphine; hydrogen; di(norbornadiene)rhodium(I) tetrafluoroborate In methanol at 60℃; under 75006 Torr; for 20h; Product distribution; Further Variations:; Reagents; | A 8% B n/a |
- 110-89-4
piperidine
- 64-18-6
formic acid
A
- 498-94-2
isonipecotic acid
B
- 56-40-6
glycine
C
- 4043-87-2
pipecolic Acid
D
- 498-95-3
nipecotic acid
| Conditions | Yield |
|---|---|
| In water at 10 - 20℃; for 1h; contact glow discharge electrolysis (500-600 V, 45 mA); | A 4.3% B 0.1% C 0.8% D 2.9% |
| Conditions | Yield |
|---|---|
| With i-Amyl alcohol; sodium |
| Conditions | Yield |
|---|---|
| at 150℃; under 0.01 Torr; |
- 119228-39-6
Piperidine-3-carboxylic acid 4-nitro-phenyl ester
A
- 100-02-7
4-nitro-phenol
B
- 498-95-3
nipecotic acid
| Conditions | Yield |
|---|---|
| With water at 37℃; pH 7.4; other nipecotic acid phenyl esters; various solutions; |
| Conditions | Yield |
|---|---|
| With Cu complex of polymer from 2,6-bis-aminomethylpyridine and 4,4'-bis-aminomethyldiphenylmethane; water In dimethyl sulfoxide at 25℃; Rate constant; var.reag.: Cu(2+) complex of 2,6-bis-benzylaminomethylpyridine; oligomers of 2,6-bis-aminomethylpyridine and 4,4'-bis-aminomethyldiphenylmethane; |
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Chemistry
Molecular Structure of Nipecotic acid (CAS NO.498-95-3):
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IUPAC Name: piperidine-3-carboxylic acid
Empirical Formula: C6H11NO2
Molecular Weight: 129.157
Index of Refraction: 1.478
Surface Tension: 40.3 dyne/cm
Density: 1.125 g/cm3
Flash Point: 114.5 °C
Enthalpy of Vaporization: 55.45 kJ/mol
Boiling Point: 265.8 °C at 760 mmHg
Chemical Properties:off-white to pale yellow-beige powder
Vapour Pressure: 0.0026 mmHg at 25°C
Uses
Nipecotic acid is a GABA reuptake inhibitor.
Safety Profile
Hazard Codes 
Xi
Risk Statements 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements 26-36-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S37/39:Wear suitable gloves and eye/face protection.
Specification
Nipecotic acid,its cas register number is 498-95-3. It also can be called (3R)-(-)-piperidin-3-ylcarboxylic acid;(+/-)-3-piperidine carboxylic acid ; 3-Piperidinecarboxylic acid ; L-nipecotic acid ; Dl-nipecotic acid ; Dl-3-piperidinecarboxylic acid ; (-)-D-nipecotic acid and so on.