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CAS No.: | 4043-87-2 |
---|---|
Name: | DL-Pipecolinic acid |
Article Data: | 79 |
Molecular Structure: | |
Formula: | C6H11NO2 |
Molecular Weight: | 129.159 |
Synonyms: | DL-2-Piperidinecarboxylic acid;(±)-2-Piperidinecarboxylic acid;(±)-Pipecolic acid;(±)-Pipecolinic acid;2-Carboxypiperidine;Acide 2-pipéridinecarboxylique;Dihydrobaikiaine;α-Pipecolinic acid; |
EINECS: | 223-737-1 |
Density: | 1.125 g/cm3 |
Melting Point: | 282 °C (dec.)(lit.) |
Boiling Point: | 265.8 °C at 760 mmHg |
Flash Point: | 114.5 °C |
Appearance: | white to light beige fine crystalline powder |
Hazard Symbols: | Xi |
Risk Codes: | 36/37/38 |
Safety: | 26-36 |
PSA: | 49.33000 |
LogP: | 0.54190 |
Conditions | Yield |
---|---|
With (R)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyldiphenylphosphine; hydrogen; di(norbornadiene)rhodium(I) tetrafluoroborate In methanol at 60℃; under 75006 Torr; for 20h; Product distribution; Further Variations:; Reagents; Solvents; ratio; | 100% |
With hydrogen; platinum(IV) oxide In ethanol at 125℃; under 18751.5 Torr; for 1h; Irradiation; microwave irradiation; | 99% |
With hydrogen; platinum(IV) oxide In ethanol at 80℃; under 5171.62 Torr; for 0.166667h; microwave irradiation; | 99% |
Conditions | Yield |
---|---|
With hydrogen; platinum(IV) oxide In water at 60℃; under 3102.9 Torr; for 5h; | 100% |
With water; platinum Hydrogenation; |
1-hydroxypiperidine-2-carboxylic acid
pipecolic Acid
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal | 89% |
(+/-)-(4-toluenesulfonyl)-piperidine-2-carboxylic acid
pipecolic Acid
Conditions | Yield |
---|---|
With naphthalene; sodium In tetrahydrofuran at -78℃; for 0.75h; | 89% |
N-acetylpiperidine-2-carbonitrile
pipecolic Acid
Conditions | Yield |
---|---|
acid hydrolysis; | 55% |
L-Lysine hydrochloride
pipecolic Acid
Conditions | Yield |
---|---|
With hydrogen; 5%-palladium/activated carbon In water at 200℃; under 5171.62 Torr; for 8h; Product distribution / selectivity; | 43% |
With hydrogen; nickel In water at 200℃; under 5171.62 - 51716.2 Torr; for 8h; Product distribution / selectivity; | 33% |
With hydrogen; 5% active carbon-supported ruthenium In water at 200℃; under 5171.62 - 51716.2 Torr; for 8h; Product distribution / selectivity; | 18% |
With hydrogen; platinum on carbon In water at 200℃; under 5171.62 Torr; for 8h; Product distribution / selectivity; | 0% |
piperidine
formic acid
A
isonipecotic acid
B
glycine
C
pipecolic Acid
D
nipecotic acid
Conditions | Yield |
---|---|
In water at 10 - 20℃; for 1h; contact glow discharge electrolysis (500-600 V, 45 mA); | A 4.3% B 0.1% C 0.8% D 2.9% |
Conditions | Yield |
---|---|
With perchloric acid; ammonium sulfamate; sodium thiocyanide at 50℃; Rate constant; piperidinium perchlorate, 18h; transnitrosating studies; |
2-nitropropane
A
2-Methoxy-5-(5,6,8,9-tetrahydro-dibenzo[c,h]acridin-7-yl)-benzenesulfonic acid; compound with perchloric acid
B
pipecolic Acid
Conditions | Yield |
---|---|
With sodium hydride 1.) water, 25 deg C, 10 min; 2.) water, 80 deg C, 3 h; further solv., var. temp. and time; Yield given. Multistep reaction; | |
With sodium hydride 1.) water, 25 deg C, 10 min; 2.) water, 80 deg C, 3 h; further solv., var. temp. and time; Yield given. Yields of byproduct given; |
(+/-)-2,6-dibromohexanoic acid
A
2,6-diaminocaproic acid
B
pipecolic Acid
Conditions | Yield |
---|---|
With copper(I) chloride; ammonium hydroxide; ammonium carbonate at 125℃; for 24h; Title compound not separated from byproducts; | A 8 % Chromat. B 44 % Chromat. |
IUPAC Name: Piperidine-2-carboxylic acid
Empirical Formula: C6H11NO2
Molecular Weight: 129.157
Canonical SMILES: C1CCNC(C1)C(=O)O
InChI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)
InChIKey: HXEACLLIILLPRG-UHFFFAOYSA-N
EINECS: 223-737-1
Product Categories: Amino ACIDS SERIES; Organic acids
storage temp.: Store at RT.
Index of Refraction: 1.478
Molar Refractivity: 32.51 cm3
Molar Volume: 114.7 cm3
Surface Tension: 40.3 dyne/cm
Density: 1.125 g/cm3
Flash Point: 114.5 °C
Enthalpy of Vaporization: 55.45 kJ/mol
Boiling Point: 265.8 °C at 760 mmHg
Vapour Pressure: 0.0026 mmHg at 25 °C
Melting Point: 282 °C (dec.)(lit.)
Classification Code of Pipecolic acid (CAS NO.4043-87-2): Mutation data
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 610mg/kg (610mg/kg) | Clinical and Experimental Pharmacology and Physiology. Vol. 21, Pg. 997, 1994. | |
mouse | LD50 | intravenous | 2200mg/kg (2200mg/kg) | Therapie. Vol. 23, Pg. 1343, 1968. |
Hazard Codes: Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 3
Hazard Note: Irritant
Pipecolic acid (CAS NO.4043-87-2), its Synonyms are 535-75-1 ; 2-Piperidinecarboxylic acid ; Acide pipecolique ; Acide piperidine-carboxylique-2 ; Hexahydropicolinic acid ; Homoproline ; Pipecolate .