CAS No.5550-12-9,Guanosine 5'-monophosphate disodium salt Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	5550-12-9
Name:	Guanosine 5'-monophosphate disodium salt
Article Data:	3

Formula:	C₁₀H₁₂N₅Na₂O₈P
Molecular Weight:	407.187
Synonyms:	5'-Guanylicacid, disodium salt (7CI,8CI,9CI);5'-GMP disodium salt;Disodium 5'-GMP;Disodium 5'-guanylate;Disodium GMP;Disodium guanosine 5'-monophosphate;Disodium guanosine 5'-phosphate;Disodium guanylate;E 627;GMP disodium salt;GMP sodium salt;Guanosine 5'-monophosphate disodium salt;Guanosine5'-phosphate disodium salt;Guanylic acid sodium salt;NSC 20265;Sodium5'-guanylate;Sodium GMP;Sodium guanosine 5'-monophosphate;Sodium guanylate;
EINECS:	226-914-1
Melting Point:	300 °C
Boiling Point:	890.2oC at 760 mmHg
Flash Point:	492.2oC
Solubility:	>50 g/L in water
Appearance:	White crystalline powder
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	22-24/25-36/37/39-27-26
PSA:	221.51000
LogP:	-1.11210

Synthetic route

: guanosine-5'-phosphoro-(2-aminoimidazole)

A: 7720-39-0
1H-imidazol-2-amine

B: 5550-12-9
guanosine 5'-monophosphate disodium

Conditions

Conditions	Yield
With trimethyl phosphite; water; sodium chloride; magnesium chloride; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid In water-d2 at 25℃; Kinetics;

: 80242-42-8
guanosine-5'-(2-methylimidazol-1-yl phosphate)

A: 693-98-1
2-methylimidazole

B: 5550-12-9
guanosine 5'-monophosphate disodium

Conditions

Conditions	Yield
With trimethyl phosphite; water; sodium chloride; magnesium chloride; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid In water-d2 at 25℃; Kinetics;

: C10H14N6O10P2(2-)*2Na(1+)

: 5550-12-9
guanosine 5'-monophosphate disodium

Conditions

Conditions	Yield
With water; zinc(II) cation pH=5.5;

: 5550-12-9
guanosine 5'-monophosphate disodium

: 85-32-5
5'-guanosine monophosphate

Conditions

Conditions	Yield
With Dowex 50W×8 resin In water at 20℃; for 0.5h;	99%
With Dowex 50WX-8 200 mesh, H+

: 288-32-4
1H-imidazole

: 5550-12-9
guanosine 5'-monophosphate disodium

: 121-44-8
triethylamine

: triethylammonium guanosin-5'-yl monophosphate P-imidazolide

Conditions

Conditions	Yield
With 2,2'-dipyridyldisulphide; triphenylphosphine In N,N-dimethyl-formamide at 20℃;	90%

...Expand

: 5550-12-9
guanosine 5'-monophosphate disodium

: 874-98-6
1-bromomethyl-3-methoxybenzene

: ((2R,3S,4R,5R)-5-(2-amino-7-(3-methoxybenzyl)-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 24h;	81%

: 15663-27-1
cisplatin

: 5550-12-9
guanosine 5'-monophosphate disodium

: cis-[Pt(NH3)2(5'-guanosine monophosphateNa2)2]Cl2

Conditions

Conditions	Yield
In water mixture is heated at 50°C for about 3-5 h with stirring; the clear soln. is left overnight at room temp.;; concn. under vacuum; pptn. with acetone, then with ether; white ppt. isfiltered off, washed with acetone, then with ether and dried in air;;	75%
In water stirring Pt-complex with 2 equiv. of ligand (room temp., 3 h, in dark);

: 5550-12-9
guanosine 5'-monophosphate disodium

: 622-95-7
4-chlorobenzyl bromide

: ((2R,3S,4R,5R)-5-(2-amino-7-(4-chlorobenzyl)-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 24h;	75%

: 5550-12-9
guanosine 5'-monophosphate disodium

: 89-92-9
2-methylbenzyl bromide

: ((2R,3S,4R,5R)-5-(2-amino-7-(2-methylbenzyl)-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 24h;	71%

: 5550-12-9
guanosine 5'-monophosphate disodium

: 100-39-0
benzyl bromide

: ((2R,3S,4R,5R)-5-(2-amino-7-benzyl-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 24h;	70%

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Chemistry

IUPAC Name:disodium [5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate
Molecular Formula:C₁₀H₁₂N₅Na₂O₈P
Molecular Weight:407.184281 g/mol
Appearance:White crystalline powder
Melting Point:300 °C
Solubility:slightly soluble in ethanol, acetone and ether
storage temp.:2-8 °C
Water Solubility:>50 g/L
FEMA:3668
EINECS:226-914-1
Synonyms of GUANYLIC ACID SODIUM SALT(5550-12-9):
GMP-5;5’-gmpdisodiumsalt;disodium5’-gmp;disodiumgmp;gmpsodiumsalt;sodium5’-guanylate;sodiumgmp;sodiumguanosine5’-monophosphate;Guanosine 5'-monophosphate disodium salt
Categories of GUANYLIC ACID SODIUM SALT(5550-12-9):
Pharmaceutical Intermediates;Biochemistry;Nucleosides, Nucleotides & Related Reagents;Nucleotides and their analogs;Nucleic acids

Uses

GUANYLIC ACID SODIUM SALT(5550-12-9) is mainly used as a condiment.

Toxicity Data With Reference

1.	cyt-ham:fbr 1 g/L	FCTOD7 Food and Chemical Toxicology. 22 (1984),623.
2.	ipr-rat LD50:3880 mg/kg	AJINO* Ajinomoto Co., Inc. (9W. 57th St., Suite 4625, New York, NY 10019)
3.	scu-rat LD50:3400 mg/kg	AJINO* Ajinomoto Co., Inc. (9W. 57th St., Suite 4625, New York, NY 10019)
4.	ivn-rat LD50:2720 mg/kg	AJINO* Ajinomoto Co., Inc. (9W. 57th St., Suite 4625, New York, NY 10019)
5.	orl-mus LD50:15 g/kg	AJINO* Ajinomoto Co., Inc. (9W. 57th St., Suite 4625, New York, NY 10019)
6.	ipr-mus LD50:5010 mg/kg	AJINO* Ajinomoto Co., Inc. (9W. 57th St., Suite 4625, New York, NY 10019)
7.	scu-mus LD50:5050 mg/kg	AJINO* Ajinomoto Co., Inc. (9W. 57th St., Suite 4625, New York, NY 10019)
8.	ivn-mus LD50:3580 mg/kg	AJINO* Ajinomoto Co., Inc. (9W. 57th St., Suite 4625, New York, NY 10019)

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Safety Information of GUANYLIC ACID SODIUM SALT(5550-12-9):
Hazard Codes:Xi
Risk Statements:36/37/38
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements:22-24/25-36/37/39-27-26
22:Do not breathe dust
24/25:Avoid contact with skin and eyes
36/37/39:Wear suitable protective clothing, gloves and eye/face protection
27:Take off immediately all contaminated clothing
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
WGK Germany:2
RTECS:MF9290000
Moderately toxic by intraperitoneal, subcutaneous, and intravenous routes. Mildly toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of PO_x, NO_x, and Na₂O.