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6000-43-7

Basic Information
CAS No.: 6000-43-7
Name: Glycine hydrochloride
Article Data: 26
Cas Database
Molecular Structure:
Molecular Structure of 6000-43-7 (Glycine hydrochloride)
Formula: C2H6ClNO2
Molecular Weight: 111.528
Synonyms: Glycine,hydrochloride (8CI,9CI);Aminoacetic acid hydrochloride;Glycocollhydrochloride;
EINECS: 227-841-8
Density: 1.27g/cm3
Melting Point: 176-180 °C(lit.)
Boiling Point: 240.9 °C at 760 mmHg
Flash Point: 99.5 °C
Solubility: Slightly soluble in water
Appearance: White crystalline powder
Risk Codes: 22
Safety: 24/25
Transport Information: UN 1789 8/PG 3
PSA: 63.32000
LogP: 0.53200
Synthetic route
70288-73-2

methoxycarbonylamino acetic acid methyl ester

6000-43-7

2-aminoethanoic acid hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; formic acid In water at 125℃; for 24h;98%
74743-61-6

(3R)-3-<(1S,5R)-3-benzyl-7-oxo-4-oxa-2,6-diazabicyclo<3.2.0>hept-2-en-6-yl>-3,4,4-trimethylthietan-2-one

A

103-82-2

phenylacetic acid

B

6000-43-7

2-aminoethanoic acid hydrochloride

C

88168-76-7

(2-RS)-2-amino-3-mercapto-2,3-dimethylbutanoic acid hydrochloride

Conditions
ConditionsYield
With hydrogenchloride for 15h; Heating;A 96%
B n/a
C n/a
116963-47-4

Ethyl N-(trichloroacetyl)-2-aminoacetate

6000-43-7

2-aminoethanoic acid hydrochloride

Conditions
ConditionsYield
With potassium hydroxide In methanol Ambient temperature;95%
56-40-6

glycine

6000-43-7

2-aminoethanoic acid hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water at 60℃; for 8h;91%
With hydrogenchloride at 50℃; under 11400.9 Torr; Equilibrium constant; Thermodynamic data; Kinetics; various temperatures, protonation;
With hydrogenchloride In water
3545-80-0

hydroxyiminoacetic acid

6000-43-7

2-aminoethanoic acid hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; tin(ll) chloride In water at 20 - 25℃; for 16h;61%
495-69-2

Hippuric Acid

6000-43-7

2-aminoethanoic acid hydrochloride

Conditions
ConditionsYield
With hydrogenchloride
15166-50-4

N-(Trichloroacetyl)glycine

6000-43-7

2-aminoethanoic acid hydrochloride

Conditions
ConditionsYield
With hydrogenchloride Heating;
367-62-4

ethyl 2-(2,2,2-trifluoroacetamido)acetate

6000-43-7

2-aminoethanoic acid hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; potassium hydroxide 1.) methanol, 2 h, r. t.; Yield given. Multistep reaction;
1068-90-2

2-acetylaminomalonic acid diethyl ester

6000-43-7

2-aminoethanoic acid hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; water
1172-18-5, 36105-20-1

flurazepam dihydrochloride

A

6000-43-7

2-aminoethanoic acid hydrochloride

B

5-chloro-2-<<2-(diethylamino)ethyl>amino>-2'-fluorobenzophenone hydrochloride

Conditions
ConditionsYield
Product distribution;
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Chemistry

Molecular Structure of 2-Aminoacetic acid hydrochloride (CAS NO.6000-43-7):

IUPAC Name: 2-Aminoacetic acid hydrochloride 
CAS: 6000-43-7
Formula: C2H6ClNO2
Molecular Weight: 111.53
EINECS: 227-841-8
H bond acceptors: 3
H bond donors: 3
Freely Rotating Bonds: 2
Polar Surface Area: 29.54 Å2
Flash Point: 99.5 °C
Storage temp: 2-8°C
Water Solubility: Slightly soluble
Sensitive: Hygroscopic
Merck: 14,4491
BRN: 3909617
Melting Point: 176-180 °C(lit.)
Enthalpy of Vaporization: 52.63 kJ/mol
Boiling Point: 240.9 °C at 760 mmHg
Vapour Pressure: 0.0123 mmHg at 25°C
InChI
InChI=1/C2H5NO2.ClH/c3-1-2(4)5;/h1,3H2,(H,4,5);1H
Smiles
C(CN)(O)=O.Cl
Product Categories: alpha-amino acids; amino acids; biochemistry; omega-aminocarboxylic acids; omega-functional alkanols, carboxylic acids, amines & halides; alphabetic; amino acids, peptides and proteins; amino acidsanalytical standards; g;life sciences standards

Toxicity Data With Reference

1.    

orl-rat LD50:3340 mg/kg

    JPMSAE    Journal of Pharmaceutical Sciences. 62 (1973),49.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of Cl and NOx.
Safety Statements about 2-Aminoacetic acid hydrochloride (CAS NO.6000-43-7):
S24/25: Avoid contact with skin and eyes.
F10: Keep under argon.
RIDADR: UN 1789 8/PG 3
WGK Germany: 2
RTECS: MC0560000

Specification

  The chemical synonyms of  2-Aminoacetic acid hydrochloride (CAS NO.6000-43-7) are Aminoethanoic acid hydrochloride ; Aminoacetic acid hydrochloride ; Glycocoll hydrochloride ; Glycine hcl ; Glycine-hcl buffer ; Glycine hydrochloride ; Glycine hydrochloride solution ; Aminoaceticacid.hcl=h-gly-oh.hcl . It shoud avoid breathing dust, vapor, mist, or gas and should be stored in a cool, dry place. Ingestion of large amounts may cause gastrointestinal irritation. Low hazard for usual industrial handling. It can be used to improve the bitter taste of beer, but also can be used in behalf of salts, nutritional supplements, flavor enhancer.