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| CAS No.: | 635-22-3 |
|---|---|
| Name: | 4-Chloro-3-nitroaniline |
| Molecular Structure: | |
|
|
|
| Formula: | C6H5ClN2O2 |
| Molecular Weight: | 172.571 |
| Synonyms: | 3-Nitro-4-chloroaniline;4-Amino-2-nitrochlorobenzene;Aniline,4-chloro-3-nitro- (7CI,8CI);(4-Chloro-3-nitrophenyl)amine; |
| EINECS: | 211-231-3 |
| Density: | 1.494 g/cm3 |
| Melting Point: | 102-106 °C |
| Boiling Point: | 344.517 °C at 760 mmHg |
| Flash Point: | 162.158 °C |
| Appearance: | ochre powder |
| Hazard Symbols: |
 T+, N
|
| Risk Codes: | 26/27/28-33-51/53 |
| Safety: | 28A-36/37-45-61 |
| Transport Information: | UN 2237 |
| PSA: | 71.84000 |
| LogP: | 2.93480 |
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- 894852-01-87-BROMO-2,2-DIMETHYL-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE
| Conditions | Yield |
|---|---|
| With isopropyl alcohol; potassium hydroxide for 0.166667h; Microwave irradiation; regioselective reaction; | 98% |
| With isopropyl alcohol; potassium hydroxide for 0.366667h; Microwave irradiation; chemoselective reaction; | 95% |
| With potassium hydroxide; nickel-incorporated hexagonal mesoporous aluminophosphate In isopropyl alcohol at 82.84℃; for 3h; | 88% |
| Conditions | Yield |
|---|---|
| With sodium nitrate; sulfuric acid at 0 - 5℃; for 3h; | 94% |
| With sulfuric acid; guanidine nitrate at 0 - 5℃; for 1h; | 75% |
| With sulfuric acid; nitric acid | |
| durch Nitrierung; |
- 24424-99-5
di-tert-butyl dicarbonate
- 13243-32-8
1-azido-3-nitro-4-chlorobenzene
A
- 635-22-3
4-Chloro-3-nitroaniline
| Conditions | Yield |
|---|---|
| With Decaborane; palladium on activated charcoal In methanol at 20℃; for 3h; | A 68% B 30% |
| Conditions | Yield |
|---|---|
| With hydrogen; iron; acetic acid; palladium dichloride In ethanol at 20 - 25℃; under 258.6 - 2327.2 Torr; | A n/a B 61% |
| With benzophenone; triethylamine In isopropyl alcohol for 2h; Product distribution; Irradiation; | A 18% B n/a |
| With hydrogenchloride; ethanol; tin(ll) chloride |
| Conditions | Yield |
|---|---|
| With sulfuric acid; nitric acid at -20℃; |
- 67-66-3
chloroform
- 112160-74-4
acetic acid-(2,4,N-trichloro-anilide)
- 99-09-2
3-nitro-aniline
- 635-22-3
4-Chloro-3-nitroaniline
- 112160-74-4
acetic acid-(2,4,N-trichloro-anilide)
- 99-09-2
3-nitro-aniline
- 635-22-3
4-Chloro-3-nitroaniline
| Conditions | Yield |
|---|---|
| With chloroform |
| Conditions | Yield |
|---|---|
| Electrolysis; |
| Conditions | Yield |
|---|---|
| Electrolysis; |
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Chemistry
IUPAC Name: 4-Chloro-3-nitroaniline
Synonyms of 4-Chloro-3-nitroaniline (CAS NO.635-22-3): 3-Nitro-4-chloroaniline ; 4-Chloro-3-nitroaniline ; Aniline, 4-chloro-3-nitro- ; Benzenamine, 4-chloro-3-nitro-
CAS NO: 635-22-3
Molecular Formula: C6H5ClN2O2
Molecular Weight: 172.57
Molecular Structure: .gif)
EINECS: 211-231-3
H bond acceptors: 4
H bond donors: 2
Freely Rotating Bonds: 2
Polar Surface Area: 49.06 ?2
Index of Refraction:1.646
Surface Tension: 62.2 dyne/cm
Density: 1.494 g/cm3
Flash Point: 162.2 °C
Enthalpy of Vaporization: 58.85 kJ/mol
Boiling Point: 344.5 °C at 760 mmHg
Vapour Pressure: 6.55E-05 mmHg at 25°C
Melting point : 102-106 °C
Appearance: ochre powder
Product Categories of 4-Chloro-3-nitroaniline (CAS NO.635-22-3): Intermediates of Dyes and Pigments;Aromatics Compounds
Uses
4-Chloro-3-nitroaniline (CAS NO.635-22-3) is used as intermediates for color former and imaging agent of color film.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| bird - wild | LD50 | oral | 100mg/kg (100mg/kg) | Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972. | |
| guinea pig | LD50 | skin | > 1gm/kg (1000mg/kg) | United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. Vol. 8EHQ-0882-0452, | |
| mouse | LD50 | intraperitoneal | 200mg/kg (200mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. Vol. 8EHQ-0882-0452, |
| mouse | LD50 | oral | 800mg/kg (800mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. Vol. 8EHQ-0882-0452, |
| rat | LD50 | intraperitoneal | 200mg/kg (200mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. Vol. 8EHQ-0882-0452, |
| rat | LD50 | oral | 400mg/kg (400mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. Vol. 8EHQ-0882-0452, |
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
Safety Information about 4-Chloro-3-nitroaniline (CAS NO.635-22-3):
Hazard Codes 
T+T,
N,
Risk Statements: 26/27/28-33-51/53
R26/27/28: Very toxic by inhalation, in contact with skin and if swallowed.
R33: Danger of cumulative effects.
R51/53: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: 28-36/37-45-61
S28: After contact with skin, wash immediately with plenty of soap-suds.
S36/37: Wear suitable protective clothing and gloves.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S61: Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR: UN 2237 6.1/PG 3
WGK Germany: 3
RTECS: BX1750000
Hazard Note: Very Toxic
HazardClass: 6.1
PackingGroup: III
HS Code: 29214210
Poison by ingestion and intraperitoneal routes. Experimental reproductive effects. Skin and eye irritant. When heated to decomposition it emits toxic fumes of NOx and Cl−.
Specification
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Dusts at sufficient concentrations can form explosive mixtures with air.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
Handling: Minimize dust generation and accumulation. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Take precautionary measures against static discharges. Use only in a chemical fume hood.
Storage: Store in a cool, dry place. Store in a tightly closed container.