CAS No.74-55-5,Ethambutol Suppliers

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Basic Information

Molecular Structure:
CAS No.:	74-55-5
Name:	Ethambutol
Article Data:	11

Formula:	C₁₀H₂₄N₂O₂
Molecular Weight:	204.313
Synonyms:	1-Butanol,2,2'-(1,2-ethanediyldiimino)bis-, [S-(R,R)]-;1-Butanol,2,2'-(ethylenediimino)di-, (+)- (8CI);(+)-Ethambutol;(+)-N,N'-Bis[1-(hydroxymethyl)propyl]ethylenediamine;(+)-S,S-Ethambutol;(2S,7S)-2,7-Diethyl-3,6-diazaoctane-1,8-diol;(S,S)-Ethambutol;Diambutol;EMB;Purderal;d-2,2'-(Ethylenediimino)bis(1-butanol);d-2,2'-(Ethylenediimino)di-1-butanol;d-Ethambutol;d-N,N'-Bis(1-hydroxymethylpropyl)ethylenediamine;
EINECS:	200-810-6
Density:	0.987 g/cm³
Melting Point:	199 - 204oC
Boiling Point:	345.342 °C at 760 mmHg
Flash Point:	113.661 °C
Solubility:	Soluble in water. Also soluble in chloroform and methylene chloride
Appearance:	white crystalline hygroscopic powder
PSA:	64.52000
LogP:	0.48920

Synthetic route

: 5856-62-2
(S)-2-aminobutan-1-ol

: 107-06-2
1,2-dichloro-ethane

: 74-55-5
ethambutol

Conditions

Conditions	Yield
In ethanol at 78 - 80℃; for 9.5h; Solvent; Temperature;	98.01%
(heating);

: C12H20N2O4

: 74-55-5
ethambutol

Conditions

Conditions	Yield
With potassium hydroxide In ethanol for 10h; Reflux;	91%

: 909567-52-8
(S,S)-N1,N2-bis(1-tert-butyldimethylsilyloxybutan-3-yl)oxamide

: 74-55-5
ethambutol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran for 24h; Heating;	80%

: (S,S)-2-[[[1-(methoxycarbonyl)propylamino]oxalyl]amino]butyric acid methyl ester

: 74-55-5
ethambutol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran Heating;	75%
Stage #1: (S,S)-2-[[[1-(methoxycarbonyl)propylamino]oxalyl]amino]butyric acid methyl ester With lithium aluminium tetrahydride In tetrahydrofuran for 48h; Heating / reflux; Stage #2: With sodium hydroxide In tetrahydrofuran; water at 20℃; for 0.5h;	36%

: 36697-75-3
2,2'-bis(4-ethyloxazoline)

: 74-55-5
ethambutol

Conditions

Conditions	Yield
With hydrogen; rhodium(IV) oxide; platinum In ethanol Ambient temperature;

: 5856-62-2
(S)-2-aminobutan-1-ol

: 106-93-4
ethylene dibromide

: 74-55-5
ethambutol

Conditions

Conditions	Yield
With potassium hydroxide

: (4S,4'S)-4,4'-Diethyl-[2,2']bioxazolidinyl

: 74-55-5
ethambutol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether Heating;

: 61051-11-4
(-)-(S)-N,N'-Bis-(2-hydroxy-1-aethyl-aethyl)-oxalsaeurediamid

: 74-55-5
ethambutol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether
Multi-step reaction with 3 steps 1: SOCl2 2: NaOH / methanol / 1 h / Heating 3: H2 / Pt-RhO2 / ethanol / Ambient temperature View Scheme

: N,N'-bis-(1-benzyloxymethyl-propyl)-ethane-1,2-diamine

: 74-55-5
ethambutol

Conditions

Conditions	Yield
With hydrogenchloride; hydrogen; 3percent Pd/C In methanol at 20℃; under 760.051 Torr; for 48h; Hydrogenolysis;

: 147315-16-0
(S,S)-2-[[[1-(methoxycarbonyl)-3-(methylsulfanyl)propylamino]oxalyl]amino]-4-(methylsulfanyl)butyric acid methyl ester

: 74-55-5
ethambutol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 64 percent / W-4 Raney nickel / methanol; H2O / Heating 2: 75 percent / lithium aluminum hydride / tetrahydrofuran / Heating View Scheme

Raw Materials

106-93-4

5856-62-2

107-06-2

Downstream Products

107-15-3

Total:91 Page 1 of 3 1 2 3 Next>>

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Chemistry

IUPAC Name: (2S)-2-[2-[[(2S)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol
Synonyms: Ethambutol;(+)-2,2-(Ethylenediimino)di-1-butanol ; (+)-2,2’-(Ethylenediimino)Di-1-butanol;(+)-n,n’-bis(1-(hydroxymethyl)propyl)ethylenediamine ; (+)-S,s-ethambutol ;(R)-2,2’-(1,2-ethanediyldiimino)Bis-1-butanol ; 2,2’-(1,2-Ethanediyldiimino)bis-,(r-(r*,r*))-1-butano ; 2’-(1,2-Ethanediyldiimino)bis-(r)-1-butano
CAS: 74-55-5
MF: C₁₀H₂₄N₂O₂
MW: 204.31
MS:
EINECS: 200-810-6
Mol File: 74-55-5.mol
Surface Tension: 38 dyne/cm
Density: 0.987 g/cm³
Flash Point: 113.7 °C
Enthalpy of Vaporization: 68.26 kJ/mol
Boiling Point: 345.3 °C at 760 mmHg
Flash Point: 95°C
Vapour Pressure: 3.9E-06 mmHg at 25°C
eat Of Vaporization:49.0 kJ/mol
Refractive Index:1.5738 (20 C)

Uses

Tibutol (74-55-5) has anti-tuberculosis effect on the common tuberculos iof anti-TB drug resistance . the product can still have inhibitation,but It's inhibitory effect is weaker than the small isoniazid, approximation with streptomycin.no effect on other bacteria and fungi.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
human	TDLo	oral	1410mg/kg/11W (1410mg/kg)	sense organs and special senses: visual field changes: eye	New Zealand Medical Journal. Vol. 111, Pg. 428, 1998.
mammal (species unspecified)	LD50	intravenous	350mg/kg (350mg/kg)	lungs, thorax, or respiration: other changes	Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 63(3), Pg. 114S, 1967.
mammal (species unspecified)	LD50	subcutaneous	890mg/kg (890mg/kg)	lungs, thorax, or respiration: other changes	Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 63(3), Pg. 114S, 1967.
man	TDLo	oral	332mg/kg/31D- (332mg/kg)	lungs, thorax, or respiration: "fibrosis, focal (pneumoconiosis)" blood: eosinophilia	Journal of Allergy and Clinical Immunology. Vol. 100, Pg. 712, 1997.
man	TDLo	oral	600mg/kg (600mg/kg)	peripheral nerve and sensation: structural change in nerve or sheath behavioral: changes in motor activity (specific assay) kidney, ureter, and bladder: other changes in urine composition	British Medical Journal. Vol. 2, Pg. 1105, 1976.
man	TDLo	oral	1200mg/kg (1200mg/kg)	skin and appendages (skin): "dermatitis, other: after systemic exposure"	British Medical Journal. Vol. 2, Pg. 1105, 1976.
mouse	LD50	intraperitoneal	1075mg/kg (1075mg/kg)	behavioral: convulsions or effect on seizure threshold	Dissertationes Pharmaceuticae et Pharmacologicae. Vol. 23, Pg. 463, 1971.
mouse	LD50	intravenous	240mg/kg (240mg/kg)	behavioral: convulsions or effect on seizure threshold	Dissertationes Pharmaceuticae et Pharmacologicae. Vol. 23, Pg. 463, 1971.
mouse	LD50	oral	8700mg/kg (8700mg/kg)	behavioral: convulsions or effect on seizure threshold	Dissertationes Pharmaceuticae et Pharmacologicae. Vol. 23, Pg. 463, 1971.
rat	LD50	oral	998mg/kg (998mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967.
women	TDLo	oral	900mg/kg/60D- (900mg/kg)	liver: "jaundice, cholestatic"	British Medical Journal. Vol. 292, Pg. 866, 1986.

Safety Profile

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Specification

Ingestion:If Tibutol (74-55-5) is swallowed, wash out mouth with water provided person is conscious. Call a physician.
Inhalation:If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
Eyes:Assure adequate flushing of the eyes by separating the eyelids with fingers.
Handling and Storage Back to Contents
Storage:Keep tightly closed. Store Tibutol (74-55-5) at 2-8 °C.
Personal Protection:Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing. Faceshield (8-inch minimum).
Exposure Effects:Irritant. Causes severe irritation. Severe lachrymator.
Fire Fighting:Extinguish: using carbon dioxide, dry chemical powder, or appropriate foam. Water spray: Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Small spills/leaks:Cover with dry lime or soda ash, pick up, keep in a closed container, and hold for waste disposal. Ventilate area and wash spill site after material pickup is complete.
Incompatibilities:Strong oxidizing agents, Strong bases, Strong reducing agents.
Decomposition:Carbon monoxide, Carbon dioxide.