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| CAS No.: | 83919-23-7 |
|---|---|
| Name: | Mometasone furoate |
| Article Data: | 15 |
| Molecular Structure: | |
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| Formula: | C27H30Cl2O6 |
| Molecular Weight: | 521.438 |
| Synonyms: | Elocon (TN);Rimelon;Ecural;9,21-Dichloro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17-(2-furoate);Nosorex;Sch 32088;[(9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] furan-2-carboxylate;Elocone;Mometasone furoate [USAN:JAN];Pregna-1,4-diene-3,20-dione,9,21-dichloro- 17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16- methyl-,(11a,16R)-;Danitin;Elocon;Mometasone furoate (JAN/USP);Flumeta;Nasonex; |
| EINECS: | 617-501-0 |
| Density: | 1.37 g/cm3 |
| Melting Point: | 218-220°C |
| Boiling Point: | 655.5 °C at 760 mmHg |
| Flash Point: | 350.2 °C |
| Appearance: | Powder |
| PSA: | 113.02000 |
| LogP: | 6.32690 |
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- 83919-23-7
Mometasone furoate
| Conditions | Yield |
|---|---|
| With N-chloro-succinimide; sulfur dioxide In dichloromethane at 10℃; for 0.5h; | 98.2% |
- 83919-23-7
Mometasone furoate
| Conditions | Yield |
|---|---|
| With hydrogenchloride; acetic acid In dichloromethane; water at 20 - 25℃; for 5h; | 96% |
- 83919-23-7
Mometasone furoate
| Conditions | Yield |
|---|---|
| With hydrogenchloride; acetic acid In water at 5 - 25℃; for 9h; Temperature; | 93.8% |
| With hydrogenchloride; acetic acid In water at -2 - 6℃; for 5h; Temperature; | 23.22 g |
- 83919-23-7
Mometasone furoate
| Conditions | Yield |
|---|---|
| With hydrogenchloride; acetic acid In dichloromethane at -5 - 40℃; for 13h; Concentration; | 93% |
- 83881-09-8
9,11-Epoxidemometasone furoate
- 83919-23-7
Mometasone furoate
| Conditions | Yield |
|---|---|
| With hydrogenchloride; acetic acid In water at -5 - 5℃; for 3h; | 86% |
| With hydrogenchloride In acetic acid for 3h; Ambient temperature; | 83% |
| With hydrogenchloride; acetic acid In water at 0 - 5℃; | 68.1 g |
- 83880-65-3
21-chloro-16α-methyl-17α-hydroxy-1,4,9(11)-pregnatriene-3,20-dione 17-(2'-furoate)
A
- 83919-23-7
Mometasone furoate
B
- 83880-66-4
17α-hydroxy-16α-methyl-9α,11β,21-trichloro-1,4-pregnadiene-3,20-dione 17-(2'-furoate)
| Conditions | Yield |
|---|---|
| With perchloric acid; 1,3-dichloro-5,5-dimethylhydantoin In tetrahydrofuran for 4h; Ambient temperature; | A 65% B 9% |
- 527-69-5
2-furancarbonyl chloride
- 83881-08-7
21-chloro-17α-hydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
A
- 83919-23-7
Mometasone furoate
| Conditions | Yield |
|---|---|
| With hydrogenchloride; acetic acid Multistep reaction; |
| Conditions | Yield |
|---|---|
| With hydrogenchloride In dichloromethane for 1.5h; Ambient temperature; | |
| With hydrogenchloride In dichloromethane for 1.5h; Mechanism; Ambient temperature; |
- 527-69-5
2-furancarbonyl chloride
- 83919-23-7
Mometasone furoate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 3.44 g / Et3N, 4-DMAP / CH2Cl2 / 6 h / Ambient temperature 2: 83 percent / conc. HCl / acetic acid / 3 h / Ambient temperature View Scheme |
- 24916-90-3
17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
- 83919-23-7
Mometasone furoate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 69 percent / 4-DMAP, CH3SO2Cl / CH2Cl2 / 4 h / Heating 2: 3.44 g / Et3N, 4-DMAP / CH2Cl2 / 6 h / Ambient temperature 3: 83 percent / conc. HCl / acetic acid / 3 h / Ambient temperature View Scheme | |
| Multi-step reaction with 3 steps 1: 69 percent / 4-DMAP / CH2Cl2 / 4 h / Heating 2: 3.44 g / Et3N, 4-DMAP / CH2Cl2 / 6 h / Ambient temperature 3: 83 percent / conc. HCl / acetic acid / 3 h / Ambient temperature View Scheme |
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Chemistry
The Molecular Structure of Mometasone furoate (CAS NO.83919-23-7):
Empirical Formula: C27H30Cl2O6
Molecular Weight: 521.4295
Nominal Mass: 520 Da
Average Mass: 521.4295 Da
Monoisotopic Mass: 520.141944 Da
Index of Refraction: 1.603
Molar Refractivity: 130.4 cm3
Molar Volume: 379.2 cm3
Surface Tension: 56.9 dyne/cm
Density: 1.37 g/cm3
Flash Point: 350.2 °C
Enthalpy of Vaporization: 101.43 kJ/mol
Boiling Point: 655.5 °C at 760 mmHg
Vapour Pressure: 4.47E-18 mmHg at 25°C
Classification Code: Anti-Inflammatory Agents;Anti-allergic agents;Drug / Therapeutic Agent;Reproductive Effect;Steroid [topical]
Mometasone furoate (CAS NO.83919-23-7)(also referred to as mometasone) is a glucocorticoid steroid.
IUPAC Name: [(8S,9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] furan-2-carboxylate
Synonyms: Mometasone furoate ; Mometasone furoate [USAN:JAN] ; 9,21-Dichloro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17-(2-furoate) ; Asmanex ; Asmanex Twisthaler ; BRN 4340538 ; Danitin ; Ecural ; Elocon ; Elocone ; Elomet ; Flumeta ; Mometasone furoate ; Nasonex ; UNII-04201GDN4R ; Pregna-1,4-diene-3,20-dione, 9,21-dichloro-17-((2-furanylcarbonyl)oxy)-11-hydroxy-16-methyl-, (11beta,16alpha)-
Uses
Mometasone furoate (CAS NO.83919-23-7) is used in the treatment of inflammatory skin disorders (such as eczema and psoriasis), allergic rhinitis (such as hay fever), and asthma for patients unresponsive to less potent corticosteroids.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LDLo | subcutaneous | 1gm/kg (1000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 4203, 1990. | |
| rat | LD50 | subcutaneous | 300mg/kg (300mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 4203, 1990. |