CAS No.86-21-5,Pheniramine Suppliers

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Basic Information

Molecular Structure:
CAS No.:	86-21-5
Name:	Pheniramine
Article Data:	26

Formula:	C16H20 N2
Molecular Weight:	240.348
Synonyms:	Pyridine,2-[a-[2-(dimethylamino)ethyl]benzyl]-(8CI); (?à)-Pheniramine;1-Phenyl-1-(2-pyridyl)-3-di-methylaminopropane; 2-[a-(2-Dimethylaminoethyl)benzyl]pyridine;3-Phenyl-3-(2-pyridyl)-N,N-dimethylpropylamine; NSC 47965; Pheniramine;Propheniramine; Prophenpyridamine; Pyriton; Tripoton
EINECS:	201-656-2
Density:	1.018 g/cm³
Melting Point:	30-34°C(lit.)
Boiling Point:	348.3 °C at 760 mmHg
Flash Point:	164.5 °C
Hazard Symbols:	F,T
Risk Codes:	11-23/24/25-39/23/24/25
Safety:	Poison by intravenous route. Human systemic effects by ingestion: central nervous system effects. When heated to decomposition it emits toxic fumes of NO_x.
PSA:	16.13000
LogP:	3.16520

Synthetic route

: 100866-24-8
3-phenyl-3-(2-pyridyl)propanal

: 124-40-3
dimethyl amine

: 86-21-5
pheniramine

Conditions

Conditions	Yield
With hydrogen; platinum(IV) oxide In toluene at 120℃; under 38000 Torr; for 12h; catalytic reductive amination;	100%

: 50599-78-5
4-dimethylamino-2-phenyl-butyronitrile

: 74-86-2
acetylene

: 86-21-5
pheniramine

Conditions

Conditions	Yield
(η5-cyclopentadienyl)-η4-cycloocta-1,5-dienecobalt(I) In toluene at 140℃; under 10640 Torr; for 36h;	85%

: 46498-51-5
3-phenyl-3-pyridin-2-yl-propan-1-ol

: 124-40-3
dimethyl amine

: 86-21-5
pheniramine

Conditions

Conditions	Yield
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; bis[2-(diphenylphosphino)phenyl] ether In toluene at 20℃; Inert atmosphere; Reflux;	84%

: 15260-65-8
2-(1-phenylvinyl)pyridine

: 201230-82-2
carbon monoxide

: 124-40-3
dimethyl amine

: 86-21-5
pheniramine

Conditions

Conditions	Yield
With hydrogen; [Rh(1,3-dimesitylimidazole-2-ylidene)(cod)Cl] In toluene at 125℃; for 24h;	80%

...Expand

: N,N-dimethyl-3-phenyl-3-(pyridin-2-ylsulfinyl)propan-1-amine borane

: 86-21-5
pheniramine

Conditions

Conditions	Yield
With methylmagnesium bromide In tetrahydrofuran; diethyl ether at 20℃;	42%

: 15260-65-8
2-(1-phenylvinyl)pyridine

: C12H12N2O4

: 86-21-5
pheniramine

Conditions

Conditions	Yield
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; 0.8C12H6N2O4(2-)HO(1-)Al(3+)0.4CF3O3S(1-)0.1Ir(3+)0.2C11H8N(1-)0.1Cl(1-) In acetonitrile at 20℃; for 6h; Inert atmosphere; Irradiation;	38%

: 109-04-6
2-bromo-pyridine

: 140-29-4
phenylacetonitrile

: 86-21-5
pheniramine

Conditions

Conditions	Yield
With sodium amide; benzene anschl. mit <2-Chlor-aethyl>-dimethyl-amin und anschl. Erhitzen mit KOH in Butan-1-ol;

: 101-82-6
2-Benzylpyridine

: 107-99-3
2-(dimethylamino)ethyl chloride

: 86-21-5
pheniramine

Conditions

Conditions	Yield
With potassium amide
With sodium
With sodium amide
With potassium amide

: 5005-36-7
phenyl-pyridin-2-yl-acetonitrile

: 86-21-5
pheniramine

Conditions

Conditions	Yield
With sodium amide; toluene anschl. mit <2-Chlor-aethyl>-dimethyl-amin und anschl. Erwaermen mit H2SO4;

: 35344-68-4
dimethyl-(3-phenyl-3-pyridin-2-yl-allyl)-amine

: 86-21-5
pheniramine

Conditions

Conditions	Yield
With palladium on activated charcoal; acetic acid Hydrogenation;
With nickel Hydrogenation;
With palladium on activated charcoal; acetic acid Hydrogenation;

Total:34 Page 1 of 1 1

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Chemistry

IUPAC Name: N,N-Dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amine
The MF of Pheniramine (CAS NO.86-21-5) is C₁₆H₂₀N₂.

The MW of Pheniramine (CAS NO.86-21-5) is 240.34.
Synonyms of Pheniramine (CAS NO.86-21-5): Pheniramine ; 2-[.alpha.-[2-(Dimethylamino)ethyl]benzyl]pyridine ; 2-Pyridinepropanamine, N,N-dimethyl-.gamma.-phenyl
Index of Refraction: 1.556
EINECS: 201-656-2
Density: 1.018 g/ml
Flash Point: 164.5 °C
Boiling Point: 348.3 °C

Uses

Pheniramine (CAS NO.86-21-5) is used as chemical reagent, fine chemicals, organic synthesis reagents, pharmaceutical intermediates.

Toxicity Data With Reference

1.	orl-wmn TDLo:14 mg/kg:CNS	MJAUAJ Medical Journal of Australia. 2 (3)(1976),110.
2.	ivn-mus LD50:48 mg/kg	AEPPAE Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 211 (1950),328.
3.	ivn-rbt LDLo:30 mg/kg	AEPPAE Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 211 (1950),328.

Safety Profile

Poison by intravenous route. Human systemic effects by ingestion: central nervous system effects. When heated to decomposition it emits toxic fumes of NO_x.