123-00-2 Usage
Description
N-(3-Aminopropyl)morpholine, also known as 3-(4-Morpholinyl)propylamine, is a colorless liquid with a faint, fishlike odor. It is a member of the class of morpholines that is morpholine substituted by a 3-aminopropyl group at the N atom. N-(3-Aminopropyl)morpholine is corrosive to tissue and produces toxic oxides of nitrogen during combustion. It is used as a chemical intermediate in various industries and serves as a catalyst and additive in the petrochemical sector.
Uses
Used in Fiber Synthesis:
N-(3-Aminopropyl)morpholine is used as a chemical intermediate for the synthesis of fibers, contributing to the development of new materials with enhanced properties.
Used in Chemical Intermediates:
N-(3-Aminopropyl)morpholine is used as a chemical intermediate in the production of various organic compounds, pharmaceuticals, agrochemicals, and dyestuffs, playing a crucial role in the synthesis of a wide range of products.
Used in Petrochemical Additives:
N-(3-Aminopropyl)morpholine is used as a catalytic agent and petrochemical additive, enhancing the efficiency and performance of various petrochemical processes.
Used in Organic Synthesis:
As an important raw material and intermediate, N-(3-Aminopropyl)morpholine is utilized in organic synthesis to create a variety of compounds with diverse applications in different industries.
Air & Water Reactions
Soluble in water.
Reactivity Profile
N-(3-Aminopropyl)morpholine behaves as an amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Hazard
Strongly irritant to tissue.
Health Hazard
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
Safety Profile
A corrosive material. Moderately toxic by several routes. A severe skin and eye irritant. Combustible. Can react with oxidizing materials. To fight fire, use alcohol foam, dry chemical. When heated to decomposition it emits toxic fumes of NOx,.
Check Digit Verification of cas no
The CAS Registry Mumber 123-00-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 3 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 123-00:
(5*1)+(4*2)+(3*3)+(2*0)+(1*0)=22
22 % 10 = 2
So 123-00-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H16N2O/c1-2-7(8)9-3-5-10-6-4-9/h7H,2-6,8H2,1H3
123-00-2Relevant articles and documents
New asymmetrical morpholinium- and 1,1-dioxidothiomorpholinium-based dicationic ionic liquid: structure, thermophysical and electrochemical properties of propylene carbonate solutions
Arkhipova, Ekaterina A.,Ivanov, Anton S.,Levin, Mikhail M.,Maslakov, Konstantin I.,Kupreenko, Stepan Yu.,Lyssenko, Konstantin A.,Savilov, Serguei V.
, (2021/08/09)
A new asymmetrical 1,1-dioxidothiomorpholinium- and morpholinium-based dicationic ionic liquid (4-ethyl-4-[3-(4-ethyl-1,1-dioxidothiomorpholin-4-ium-4-yl)propyl]morpholin-4-ium tetrafluoroborate (EtDTMC3EtM·2BF4)) was synthesized in four stages and characterized by 1H, 13C, 1H,1H–COSY NMR, single X-ray diffraction, XPS spectroscopy and simultaneous thermal analysis. Electrical conductivities of several EtDTMC3EtM·2BF4 solutions in propylene carbonate (PC) were measured in the 298 – 368 K temperature range and analyzed using the Arrhenius, Litovitz, and Vogel–Fulcher–Tammann (VFT) equations.
Highly Selective Butyrylcholinesterase Inhibitors with Tunable Duration of Action by Chemical Modification of Transferable Carbamate Units Exhibit Pronounced Neuroprotective Effect in an Alzheimer's Disease Mouse Model
Hoffmann, Matthias,Stiller, Carina,Endres, Erik,Scheiner, Matthias,Gunesch, Sandra,Sotriffer, Christoph,Maurice, Tangui,Decker, Michael
, p. 9116 - 9140 (2019/11/03)
In this study, the carbamate structure of pseudo-irreversible butyrylcholinesterase (BChE) inhibitors was optimized with regard to a longer binding to the enzyme. A set of compounds bearing different heterocycles (e.g., morpholine, tetrahydroisoquinoline, benzimidazole, piperidine) and alkylene spacers (2 to 10 methylene groups between carbamate and heterocycle) in the carbamate residue was synthesized and characterized in vitro for their binding affinity, binding kinetics, and carbamate hydrolysis. These novel BChE inhibitors are highly selective for hBChE over human acetycholinesterase (hAChE), yielding short-, medium-, and long-acting nanomolar hBChE inhibitors (with a half-life of the carbamoylated enzyme ranging from 1 to 28 h). The inhibitors show neuroprotective properties in a murine hippocampal cell line and a pharmacological mouse model of Alzheimer's disease (AD), suggesting a significant benefit of BChE inhibition for a disease-modifying treatment of AD.
INHIBITORS OF BACTERIAL GLYCOSYL TRANSFERASES
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Paragraph 00366; 00437-00438, (2016/12/22)
Described herein are compounds of Formula (I'), Formula (IA), Formulae (I)-(VII), pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrug sthereof. The invention also provides pharmaceutical compositions of the compounds for human and veterinary use. Compounds of the present invention are useful for inhibiting bacterial growth and therefore are useful in treating and/or preventing bacterial infections. Methods of using the compounds for treating and/or preventing a bacterial infection in a subject are also described.