15978-94-6Relevant articles and documents
Crystal structures of cis-diiododiammine platinum and trans-diazidodiammine platinum
Vasilchenko,Zadesenets,Baidina,Piryazev,Romanenko
, p. 1689 - 1692 (2018/02/09)
Platinum(II) complexes cis-[Pt(NH3)2I2] (1) and trans-[Pt(NH3)2(N3)2] (2) are structurally characterized separately for the first time. The crystallographic data are as follows: for 1, a = 7.0065(6) ?, b = 6.8714(6) ?, c = 7.4106(8) ?, β = 108.432(7)°, space group P21/m, Z = 2, ρcalc = 4.739 g/cm3; for 2, a = 8.1337(5) ?, b = 11.5821(7) ?, c = 6.9705(5) ?, β = 107.256(2)°, space group P21/c, Z = 4, ρcalc = 3.318 g/cm3. Platinum atoms have a square planar environment; the main structure-forming factor is the presence of intermolecular hydrogen bonds forming chain motifs in the structure of 1 and a threedimensional framework in the structure of 2.
METAL COMPLEX AND ANTICANCER AGENT CONTAINING THE SAME
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Paragraph 0083, (2017/02/23)
PROBLEM TO BE SOLVED: To provide a platinum complex more excellent in anticancer activity than the coexisting platinum anticancer such as cisplatin and oxaliplatin, and also reduced in side-effects. SOLUTION: Provided is a platinum complex represented by formula (1) as a myo-inositol-1,2,3,4,5,6-hexakisphosphate derivative, and also provided is a platinum complex such as a (1,10-phenanthroline)(N-9-anthranilic methyl-1, 4-butane diamine) platinum [m and n respectively independently denote 1 or 2 and m+n denotes 3]. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT
PLATINUM COMPOUND HAVING AMINO OR ALKYLAMINO-CONTAINING SUCCINIC ACID DERIVATIVES AS LEAVING GROUP, PREPARTION METHOD THEREOF, AND USE THEREOF
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Paragraph 0172; 0173, (2014/12/09)
Disclosed are a category of platinum compounds having amino- or alkylamino-containing succinato derivatives as leaving group, or pharmaceutically acceptable salts thereof, preparation method thereof, and medicinal compositions containing the compounds. Also disclosed is a use of the compounds in treating cell proliferative diseases, especially cancers. The platinum compounds of the present invention have high water solubility and small toxic side effect.
