100049-49-8Relevant articles and documents
A biomimetic approach to the synthesis of the core structure of the marine sponge terpene halichonadin G
Saito, Kenta,Nishimori, Ayumu,Mimura, Rika,Nakano, Keiji,Kotsuki, Hiyoshizo,Masuda, Toshiya,Ichikawa, Yoshiyasu
, p. 7041 - 7043 (2013)
A pathway for the biosynthesis of halichonadin G involving the unique action of ugiase and isocyanide oxidase is proposed. This hypothesis was tested in a biomimetic approach to the synthesis of the core structural unit of this marine sponge terpene, which relies on a key Ugi coupling reaction and an isocyanide-to-isocyanate oxidative transformation. The results of this effort demonstrate that the biomimetic strategy can be employed to construct the core structure of halichonadin G in an efficient manner. A unique pathway for the biosynthesis of the marine sponge terpene halichonadin G is proposed. On the basis of this proposal, a biomimetic approach involving a Ugi coupling reaction is designed and applied to the efficient construction of the core structure of halichonadin G. Copyright
